Azacitidine USP Related Compound B CAS 6974-32-9
| CAS No. | 6974-32-9 |
| Molecular Formula | C28H24O9 |
| Molecular Weight | 504.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Azacitidine USP Related Compound B is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Azacitidine USP Related Compound B (CAS 6974-32-9, C28H24O9) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Azacitidine USP Related Compound B (C28H24O9) contains a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Azacitidine USP Related Compound B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H24O9 |
| Molecular Weight | 504.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Azacitidine Standards
- Azacitidine Impurity 26 (CAS 63-39-8)
- Azacitidine Triphosphate (CAS 2226-74-6)
- Azacitidine Impurity 89 (CAS 69350-76-1)
- Azacitidine Impurity 44 (CAS CATO-C4X-138844)
- Azacitidine Impurity 83 (CAS CATO-C4X-138883)
- Azacitidine Impurity 82 (CAS CATO-C4X-138882)
- Azacitidine Impurity 13 (CAS CATO-C4X-138813)
- Azacitidine Impurity 25 (CAS CATO-C4X-138825)
Recommended Standards
- β-L-Ribofuranose 1-Acetate 2,3,5-Tribenzoate (CAS 3080-30-6)
- 7,7’-(Carbonyldiimino)bis(4-hydroxynaphthalene-2-sulfonic Acid) (CAS 134-47-4)
- Clofarabine Impurity 4 (CAS 70832-64-3)
- 6,6'-(Carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonic acid) (CAS 6266-54-2)
- Potassium Clavulanate EP Impurity J HCl (CAS 7677-21-6)
- Butenafine Impurity 18 (CAS CATO-C4X-159618)
- Esmolol Impurity 96 (CAS CATO-C4X-189196)
- (4-Methoxy-5-(methoxycarbonyl)thiophen-2-yl)boronic acid (CAS 2251714-63-1)
- Rasagiline Impurity 14 HCl (CAS 200628-33-7)
- 3-Chloro-6-(trifluoromethyl)pyridine-2-methanol (CAS 1227584-33-9)
- Tert-butyl 6-formyl-1,3-dihydro-2H-pyrrolo[3,4-c]pyridine-2-carboxylate (CAS 1824323-60-5)
- 2-(2H-benzo[d][1,2,3]triazol-2-yl)ethan-1-ol (CAS 939-72-0)
- ethyl 2-[(2-chlorobenzoyl)amino]-2-(diisopropoxyphosphoryl)-3,3,3-trifluoropropanoate (CAS 340032-46-4)
- Semaglutide impurity 109 (CAS CATO-C4X-2226109)
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