Rebamipide impurity 19 CAS 698-16-8
| CAS No. | 698-16-8 |
| Molecular Formula | C7H6ClNO |
| Molecular Weight | 155.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Rebamipide impurity 19 (CAS 698-16-8) is a certified pharmaceutical impurity reference standard with the molecular formula C7H6ClNO and a molecular weight of 155.58 g/mol.
Rebamipide impurity 19 (C7H6ClNO) contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6ClNO |
| Molecular Weight | 155.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Rebamipide Standards
- Rebamipide Impurity 14 (CAS 619-56-7)
- Rebamipide Impurity 1 (CAS 94670-39-0)
- Rebamipide Impurity 47 (CAS 855177-00-3)
- Rebamipide Impurity 59 (CAS CATO-C4X-152359)
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- Rebamipide Impurity 31 (CAS CATO-C4X-152331)
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- Rebamipide Impurity 11 (CAS 4876-10-2)
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