Rizatriptan Impurity 12 CAS 700-37-8
| CAS No. | 700-37-8 |
| Molecular Formula | C6H3ClFNO2 |
| Molecular Weight | 175.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Rizatriptan Impurity 12 (CAS 700-37-8, C6H3ClFNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Rizatriptan Impurity 12 (C6H3ClFNO2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 175.54 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H3ClFNO2 |
| Molecular Weight | 175.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Rizatriptan Standards
- Rizatriptan Impurity 15 (CAS 114094-45-0)
- Rizatriptan Impurity 24 (CAS 119192-11-9)
- Rizatriptan Impurity 13 (CAS 91192-27-7)
- Rizatriptan Impurity 11 (CAS 119192-10-8)
- Rizatriptan Impurity 10 (CAS 63516-03-0)
- Rizatriptan Impurity 1 (CAS 212248-62-9)
- Rizatriptan Impurity 15 (CAS 6085-94-5)
- Rizatriptan Impurity 12 (CAS 119192-09-5)
Recommended Standards
- Gefitinib Impurity 46 (CAS 2106-49-2)
- 2-Chloro-5-fluoropyrimidine-4-carboxamide (CAS 2058321-73-4)
- Gefitinib Impurity 45 (CAS 350-30-1)
- N-(4-Chlorophenyl-1,2,3,4,5,6-13C6)acetamide (CAS 1329611-30-4)
- Roxatidine Impurity 75 (CAS CATO-C4X-121375)
- Etomidate impurity 55 (CAS CATO-C4X-188455)
- Glipizide EP Impurity F (CAS 192118-08-4)
- 4-Chloro-5-iodo-2,6-dimethylpyrimidine (CAS 83410-16-6)
- 2-Bromo-1-(2-fluorobenzofuran-5-yl)ethan-1-one (CAS 2757324-51-7)
- 3-(Chloromethyl)-2-methylfuran (CAS 14497-33-7)
- CUDA (CAS 479413-68-8)
- 2-(2-Chloronaphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2621937-36-6)
- (S)-3-(2-Fluoroacetyl)-4-isopropyloxazolidin-2-one (CAS 150895-71-9)
- Neuropeptide Y (free acid) (human, rat) trifluoroacetate salt (CAS 99575-89-0)
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