4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one CAS 701937-51-1
| CAS No. | 701937-51-1 |
| Molecular Formula | C9H11F2N3O4 |
| Molecular Weight | 263.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one (CAS 701937-51-1), a certified reference material (molecular formula C9H11F2N3O4, MW 263.20 g/mol) for analytical method development and quality control.
The molecular framework of 4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one (C9H11F2N3O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H11F2N3O4 |
| Molecular Weight | 263.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Amino Standards
- 4-Amino-1-((4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (CAS 103882-84-4)
- 5-Amino-1-(3,4-difluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (CAS 1416348-31-6)
- (S)-2-Amino-4-(2-(trifluoromethoxy)phenyl)butanoic acid (CAS 1260590-74-6)
- (R)-2-Amino-4-(3-(trifluoromethoxy)phenyl)butanoic acid (CAS 1260607-86-0)
- 3-Amino-2-(3-(trifluoromethoxy)benzyl)propanoic acid (CAS 1260607-90-6)
- (S)-2-Amino-4-(4-(trifluoromethoxy)phenyl)butanoic acid (CAS 1260610-29-4)
- (R)-3-amino-2-(2-(trifluoromethoxy)benzyl)propanoic acid (CAS 1260611-02-6)
- (R)-3-amino-2-(4-(trifluoromethoxy)benzyl)propanoic acid (CAS 1260611-63-9)
Recommended Standards
- 4,4'-Selenodianiline (CAS 65130-25-8)
- 5-((2-Nitrophenoxy)methyl)furan-2-carboxylic acid (CAS 364621-84-1)
- 3-(Carboxymethyl)-1H-indole-2,5-dicarboxylic acid (CAS 727687-76-5)
- 5-(4-Methoxy-2-nitrophenyl)furan-2-carboxylic acid (CAS 95611-90-8)
- 1-(Chloroacetylamino) Adamantane (CAAA) (CAS 5689-59-8)
- 4-(4-Chlorophenyl)-2-{[3-(trifluoromethyl)phenyl]sulfanyl}pyridine-3-carbonitrile (CAS 339103-62-7)
- 5-amino-2-benzyl-1,3-oxazole-4-carbonitrile (CAS 887748-74-5)
- 6-(Azetidin-3-yl)picolinonitrile (CAS 1260852-58-1)
- n-(4-Carbamimidoylphenyl)acetamide, acetic acid (CAS 1417637-55-8)
- (E)-4-((naphthalen-2-ylmethylene)amino)-2-nitroaniline (CAS 1351487-84-7)
- 4,4-Difluorooctahydrocyclopenta[c]pyrrole hydrochloride (CAS 1421601-42-4)
- 4-Hydroxypropofol 1-O-b-D-glucuronide (CAS 114991-25-2)
- 3-(2,4-Dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzaldehyde (CAS 1261953-11-0)
- Prolactin-Releasing Peptide (12-31) (human) (CAS 235433-36-0)
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