Memantine impurity 51 CAS 702-80-7
| CAS No. | 702-80-7 |
| Molecular Formula | C11H17Cl |
| Molecular Weight | 184.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Memantine impurity 51 is closely related to chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Memantine impurity 51 (CAS 702-80-7) is a certified pharmaceutical impurity reference standard with the molecular formula C11H17Cl and a molecular weight of 184.71 g/mol.
Memantine impurity 51 (C11H17Cl) contains chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H17Cl |
| Molecular Weight | 184.71 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Memantine Standards
- Memantine Related Compound B (CAS 707-37-9)
- Memantine Impurity 11 (CAS 41100-45-2)
- Memantine Impurity 43 (CAS 3717-40-6)
- Memantine (CAS 19982-08-2)
- Memantine Related Compound 3 (CAS 1262583-10-7)
- Memantine Impurity 32 (CAS 26919-42-6)
- Memantine Impurity 28 (CAS 63971-25-5)
- Memantine Impurity 65 (CAS CATO-C4X-105865)
Recommended Standards
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- Paliperidone Impurity 28 (CAS 55665-95-7)
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- Methyl 4-hydroxy-1-phenylcyclohexanecarboxylate (CAS 1706457-90-0)
- Methyl 2-amino-3,5-dibromo-4-methoxybenzoate (CAS 2092263-35-7)
- Insulin Degludec Impurity 25 (CAS CATO-C4X-215725)
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