Captopril Impurity 8 CAS 74345-73-6
| CAS No. | 74345-73-6 |
| Molecular Formula | C6H9ClO2S |
| Molecular Weight | 180.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Captopril Impurity 8.
Captopril Impurity 8 (CAS 74345-73-6) is a certified pharmaceutical impurity reference standard with the molecular formula C6H9ClO2S and a molecular weight of 180.65 g/mol.
Owing to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Captopril Impurity 8 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 180.65 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Captopril Impurity 8 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H9ClO2S |
| Molecular Weight | 180.65 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Captopril Standards
- Captopril Impurity 31 (CAS 69570-39-4)
- Captopril Impurity 26 (CAS 51161-88-7)
- Captopril EP Impurity E (CAS 23500-15-4)
- Captopril Impurity 37(Piracetam Impurity E) (CAS 1249080-59-8)
- Captopril EP Impurity D (CAS 56970-78-6)
- Captopril EP Impurity G (R-Isomer) (CAS 74431-52-0)
- Captopril EP Impurity G (CAS 33325-40-5)
- Captopril EP Impurity G (S-Isomer) (CAS 76497-39-7)
Recommended Standards
- Di-tert-butylphosphine chloride (CAS 13716-10-4)
- Spiro[2.2]pentan-1-ylmethanesulfonyl chloride (CAS 2137750-67-3)
- 4-(4-Chlorophenyl)-2-methyl-1-butene (CAS 106897-78-3)
- Milnacipran Impurity 4 (CAS 64805-64-7)
- Vitamin K1 Impurity 47 (CAS 2682052-39-5)
- Dacomitinib Impurity 16 (CAS CATO-C4X-208616)
- N-Nitroso Oxcarbazepine EP Impurity D (CAS CATO-C4X-116432)
- 5-bromo-4-(methylsulfanyl)pyrimidin-2-amine (CAS 1503752-08-6)
- Ethyl 4,6-diethoxypyridazine-3-carboxylate (CAS 679405-89-1)
- (4-Amino-2,5-difluorophenyl)methanol (CAS 1346764-06-4)
- 1220036-57-6 2309AD 4-[2-(Isopentyloxy)ethyl]piperidine hydrochloride C12H26ClNO (CAS 1220036-57-6)
- Nifedipine Pyrimidine Impurity (CAS 80742-11-6)
- 6-(4-Aminophenethyl)-3-((2-(tert-Butyl)-4-(hydroxymethyl)-5-methylphenyl)thio)-6-cyclohexyl-4-hydroxy-5,6-dihydro-2H-pyran-2-one (CAS 197915-48-3)
- [Glu]17-Liraglutide (CAS CATO-C4X-199236)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com