1-(3-Chloro-4-fluoro-2-hydroxyphenyl)ethan-1-one CAS 703-97-9
| CAS No. | 703-97-9 |
| Molecular Formula | C8H6ClFO2 |
| Molecular Weight | 188.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 1-(3-Chloro-4-fluoro-2-hydroxyphenyl)ethan-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
1-(3-Chloro-4-fluoro-2-hydroxyphenyl)ethan-1-one (CAS 703-97-9) is a high-purity analytical reference standard with the molecular formula C8H6ClFO2 and a molecular weight of 188.58 g/mol.
The molecular framework of 1-(3-Chloro-4-fluoro-2-hydroxyphenyl)ethan-1-one (C8H6ClFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H6ClFO2 |
| Molecular Weight | 188.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-Chloro-3-fluorophenylacetic Acid (CAS 1000523-07-8)
- 2-Chloro-3-fluoro-4-methoxybenzaldehyde (CAS 1002344-90-2)
- 4-Chloro-2-fluoro-3-methoxybenzaldehyde (CAS 1002344-97-9)
- 2-Chloro-5-fluoro-4-methylbenzoic acid (CAS 103877-61-8)
- 1-(4-Chloro-5-fluoro-2-hydroxyphenyl)ethan-1-one (CAS 105533-69-5)
- 1-(4-Chloro-2-fluoro-6-hydroxyphenyl)ethanone (CAS 1110663-22-3)
- 6-Chloro-2-fluoro-3-methoxybenzaldehyde (CAS 112641-64-2)
- 4-Chloro-2-fluoro-6-methoxybenzaldehyde (CAS 1158916-85-8)
Recommended Standards
- 4-Chloro-2-fluorophenylacetic Acid (CAS 194240-75-0)
- 1-(3-Chloro-5-fluoro-2-hydroxyphenyl)ethan-1-one (CAS 445-38-5)
- 3-Chloro-4-fluoro-2-methoxybenzaldehyde (CAS 1896922-66-9)
- 1-(5-Chloro-4-fluoro-2-hydroxyphenyl)ethan-1-one (CAS 865451-01-0)
- (R)-3,3-Difluoro-1-methylpiperidin-4-ol (CAS 2306252-98-0)
- 1-(4-((4-Methoxynaphthalen-1-yl)sulfonyl)piperazin-1-yl)ethan-1-one (CAS 941264-04-6)
- 5,6-Dibromo-2-methyl-7-(trifluoromethyl)quinazolin-4(3H)-one (CAS 2573800-53-8)
- 4-[(4-Chloro-2-nitrophenoxy)methyl]piperidinehydrochloride (CAS 1220032-98-3)
- (S)-3-Aminohexanoic acid (CAS 91298-66-7)
- (E)-N'-[7-(3-Chlorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]-N,N-dimethylmethanimidamide (CAS 303145-80-4)
- 4-(Methylsulfanyl)butanoic acid (CAS 32391-97-2)
- Furan-2-thiol (CAS 13129-35-6)
- 2,3-Dihydro-1H-pyrrolo[3,2-b]pyridine-5-carboxylic acid (CAS 1548017-53-3)
- Semaglutide Impurity 163 (x TFA Salt) (CAS CATO-C4X-2226163)
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