1-(5-Chloro-4-fluoro-2-hydroxyphenyl)ethan-1-one CAS 865451-01-0
| CAS No. | 865451-01-0 |
| Molecular Formula | C8H6ClFO2 |
| Molecular Weight | 188.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(5-Chloro-4-fluoro-2-hydroxyphenyl)ethan-1-one.
1-(5-Chloro-4-fluoro-2-hydroxyphenyl)ethan-1-one (CAS 865451-01-0) is a high-purity analytical reference standard with the molecular formula C8H6ClFO2 and a molecular weight of 188.58 g/mol.
1-(5-Chloro-4-fluoro-2-hydroxyphenyl)ethan-1-one (C8H6ClFO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(5-Chloro-4-fluoro-2-hydroxyphenyl)ethan-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6ClFO2 |
| Molecular Weight | 188.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-Chloro-3-fluorophenylacetic Acid (CAS 1000523-07-8)
- 2-Chloro-3-fluoro-4-methoxybenzaldehyde (CAS 1002344-90-2)
- 4-Chloro-2-fluoro-3-methoxybenzaldehyde (CAS 1002344-97-9)
- 2-Chloro-5-fluoro-4-methylbenzoic acid (CAS 103877-61-8)
- 1-(4-Chloro-5-fluoro-2-hydroxyphenyl)ethan-1-one (CAS 105533-69-5)
- 1-(4-Chloro-2-fluoro-6-hydroxyphenyl)ethanone (CAS 1110663-22-3)
- 6-Chloro-2-fluoro-3-methoxybenzaldehyde (CAS 112641-64-2)
- 4-Chloro-2-fluoro-6-methoxybenzaldehyde (CAS 1158916-85-8)
Recommended Standards
- 1-(3-Chloro-5-fluoro-2-hydroxyphenyl)ethan-1-one (CAS 445-38-5)
- 2-(3-Chloro-2-fluorophenyl)acetic Acid (CAS 261762-96-3)
- 1-(3-Chloro-4-fluoro-2-hydroxyphenyl)ethan-1-one (CAS 703-97-9)
- 2-(3-Chloro-5-fluorophenyl)acetic acid (CAS 202001-00-1)
- 3-{[2-Bromo-4-(sec-butyl)phenoxy]-methyl}piperidine hydrochloride (CAS 1220018-61-0)
- 2-(4-(2-Oxo-5-((prop-2-yn-1-yloxy)methyl)oxazolidin-3-yl)phenyl)acetic acid (CAS 43148-98-7)
- N-(2,4-Diaminoquinazolin-6-yl)-2-(3-(trifluoromethyl)phenyl)acetamide (CAS 55096-42-9)
- (S)-2-amino-N-isopropyl-2-phenylacetamide hydrochloride (CAS 481658-77-9)
- 4-(1-Chloroethyl)-1-phenyl-1h-1,2,3-triazole (CAS 1394042-41-1)
- Diquinoxalino[2,3-a:2',3'-c]phenazine (CAS 214-83-5)
- (R)-4-(Pyrrolidin-2-yl)phenol hydrochloride (CAS 2055848-95-6)
- 7,7-difluoro-2-oxabicyclo[4.1.0]heptane-1-carbonitrile (CAS 1955553-05-5)
- (2S,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(3,5-dimethoxyphenyl)-2-hydroxypropanoic acid (CAS 959581-18-1)
- Tau Peptide (268-282) trifluoroacetate salt (CAS 330456-37-6)
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