Axitinib Impurity N29 CAS 70315-70-7
| CAS No. | 70315-70-7 |
| Molecular Formula | C7H4IN3O2 |
| Molecular Weight | 289.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Axitinib Impurity N29 (C7H4IN3O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Axitinib Impurity N29 (CAS 70315-70-7) is a certified pharmaceutical impurity reference standard with the molecular formula C7H4IN3O2 and a molecular weight of 289.03 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4IN3O2 |
| Molecular Weight | 289.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 3 |
Related Axitinib Standards
- Axitinib Impurity 7 (CAS 944835-85-2)
- Axitinib Impurity 21 (CAS CATO-C4X-107121)
- Axitinib Impurity 43 (CAS 1959572-97-4)
- Axitinib Impurity 64 (CAS CATO-C4X-107164)
- Axitinib Impurity 36 (CAS CATO-C4X-107136)
- Axitinib Impurity N7 (CAS 2242852-05-5)
- Axitinib Impurity N24 (CAS 119-80-2)
- Axitinib Impurity 53 (CAS CATO-C4X-107153)
Recommended Standards
- 7-Iodofuro[3,2-c]pyridine-2-carboxylic Acid (CAS 895126-66-6)
- 2,3-bis(chloranyl)-6,7-dinitro-quinoxaline 2,3-dichloro-6,7-dinitroquinoxaline 2379-61-5 A816911 (CAS 2379-61-5)
- 7-Iodo-5-nitrobenzofuran (CAS 478617-58-2)
- 4-Bromo-2,6-dinitrophenyl acetaldehyde (CAS 1000340-99-7)
- Diosmin EP Impurity C-d4 (Isorhoifolin-d4) (CAS CATO-C4X-115613)
- Folic Acid EP Impurity E Sulfate (CAS CATO-C4X-139541)
- Upadacitinib Impurity 24 (CAS 1869118-24-0)
- 3-Methoxy-3-oxoprop-1-ene-1-sulfonic acid (CAS 1909358-92-4)
- Amyloid β-Protein (31-35) (CAS 149385-65-9)
- Ethyl 6-hydroxy-4-(4-methoxyphenyl)-2-phenyl-4,5-dihydropyrimidine-5-carboxylate (CAS 400078-30-0)
- 3-Methoxybenzylisocyanide (CAS 177762-74-2)
- 2-(2,3-Dichlorophenyl)quinazoline (CAS 1451359-50-4)
- 4-(4-Methoxyphenyl)piperidine (CAS 67259-62-5)
- Peptide 434 (CAS CATO-CPTD788434)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com