Folic Acid EP Impurity E Sulfate CAS CATO-C4X-139541
| CAS No. | CATO-C4X-139541 |
| Molecular Formula | C26H24N12O7 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Folic Acid EP Impurity E Sulfate (CAS CATO-C4X-139541), a pharmacopoeial impurity reference standard (molecular formula C26H24N12O7H2O4S, MW 714.63 g/mol) used for the identification and quantification of trace impurities in APIs.
Folic Acid EP Impurity E Sulfate (C26H24N12O7H2O4S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H24N12O7 H2O4S |
| Molecular Weight | 714.63 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 12 |
| Sulfur Atoms | 1 |
Related Folic Standards
- Folic acid EP Impurity B (CAS 1004-75-7)
- Folic Acid Hydrate (CAS 1174277-30-5)
- Folic Acid Impurity 45 (CAS 1182291-60-6)
- Folic Acid EP Impurity D (CAS 119-24-4)
- Folic Acid-13C5 (CAS 1207282-75-4)
- Folic Acid EP Impurity E (CAS 1391068-26-0)
- Folic Acid EP Impurity F (CAS 1391194-56-1)
- Folic Acid EP Impurity F HCl (CAS 1391194-56-1(free base))
Recommended Standards
- Empagliflozin impurity 180 (CAS CATO-C4X-1065180)
- Amiodarone EP Impurity A (CAS 23551-25-9)
- Elagolix Impurity 37 (CAS CATO-C4X-206837)
- 3-(3-Chloro-1H-1,2,4-triazol-1-yl)adamantan-1-amine hydrochloride (CAS 1371098-89-3)
- 4-(Fmoc-amino)benzyl Alcohol (CAS 475160-83-9)
- N-Methyl-3-(5-nitrofuran-2-yl)-1H-1,2,4-triazol-5-amine (CAS 10187-84-5)
- 2-Chloro-N-(2-(N-isopropylacetamido)cyclohexyl)acetamide (CAS 1353945-80-8)
- 4-Methyl-2-Nitrophenol (CAS 119-33-5)
- 2-Morpholino-5-nitrobenzotrifluoride (CAS 54672-11-6)
- Semaglutide impurity 67 (CAS CATO-C4X-222667)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com