Paliperidone Impurity 47 CAS 70381-47-4
| CAS No. | 70381-47-4 |
| Molecular Formula | C11H12N2O2 |
| Molecular Weight | 204.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Paliperidone Impurity 47 (CAS 70381-47-4, C11H12N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Paliperidone Impurity 47 (C11H12N2O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 204.23 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C11H12N2O2 |
| Molecular Weight | 204.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Nitrogen Atoms | 2 |
Related Paliperidone Standards
- Paliperidone Impurity 93 (CAS CATO-C4X-172493)
- Paliperidone Impurity 100 (CAS CATO-C4X-1724100)
- Paliperidone Impurity 46 (CAS 1008796-23-3)
- Paliperidone Impurity 121 (CAS 24016-03-3)
- Paliperidone USP Related Compound A (CAS 849903-79-3)
- Paliperidone Impurity 66 (CAS CATO-C4X-172466)
- Paliperidone Impurity 129 (CAS 46020-63-7)
- Paliperidone Impurity 165 (CAS CATO-C4X-1724165)
Recommended Standards
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- Ozagrel Impurity 22 (CAS CATO-C4X-197122)
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- Olprinone Impurity 27 (CAS CATO-C4X-204327)
- Nifedipine EP Impurity D (CAS 14205-39-1)
- Toremifene impurity 6 (CAS CATO-C4X-13976)
- Pregabalin Impurity 132 (CAS CATO-C4X-1312132)
- H-Cys(Acm)-OH.H2O (CAS 213475-48-0)
- Linezolid USP Related Compound C (CAS 168828-90-8)
- Ethyl 6-amino-1H-benzo[d]imidazole-4-carboxylate (CAS 1805837-53-9)
- Methyl (2E)-3-(dimethylamino)-2-[(4Z)-4-[(dimethylamino)methylene]-1-(4-methoxyphenyl)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl]acrylate (CAS 1379821-58-5)
- Cefpodoxime Proxetil EP Impurity E (CAS CATO-C4X-157951)
- 5,7-Dinitroindoline (CAS 67932-53-0)
- (9-D-Asp) Semaglutide X Sodium salt (CAS CATO-CPTD788617)
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