Macitentan Impurity 9 CAS 706811-25-8
| CAS No. | 706811-25-8 |
| Molecular Formula | C10H7BrN2O2 |
| Molecular Weight | 267.08 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Macitentan Impurity 9 (CAS 706811-25-8, C10H7BrN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Macitentan Impurity 9 (C10H7BrN2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H7BrN2O2 |
| Molecular Weight | 267.08 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Macitentan Standards
- Macitentan impurity 51 (CAS CATO-C4X-117551)
- Macitentan impurity 53 (CAS 2211054-46-3)
- Macitentan Impurity 13 (CAS 3974-18-3)
- Macitentan Impurity 36 (CAS CATO-C4X-117536)
- Macitentan Impurity 10 (CAS 149506-35-4)
- Macitentan Impurity 38 (CAS 2211054-17-8)
- Macitentan Impurity 42 (CAS CATO-C4X-117542)
- Macitentan Impurity 11 (CAS 1393813-40-5)
Recommended Standards
- 4-(5-Bromo-2-furyl)benzoic acid 5183AE 53782-66-4 C11H7BrO3 (CAS 53782-66-4)
- 1-(2-Bromopropyl)-4-(trifluoromethyl)benzene (CAS 1021927-60-5)
- N-(5-bromopyridin-2-yl)-1H-pyrazole-5-carboxamide (CAS 936033-32-8)
- 1-Bromo-2-(4-fluorophenoxy)benzene (CAS 1055987-64-8)
- Beraprost Impurity 32 (CAS CATO-C4X-218432)
- Lincomycin Impurity 38 (CAS CATO-C4X-134238)
- Urapidil Impurity 83 (CAS CATO-C4X-192483)
- 1-Methyl-5-propyl-1H-pyrazole-3-carboxylic acid amide, 97% (CAS 1185292-78-7)
- 3-(4-Isobutylphenyl)-1H-pyrazole (CAS 948293-30-9)
- MP A08 (CAS 219832-49-2)
- N-(2,7-Dichloro-9H-fluoren-4-yl)acetamide (CAS 73664-41-2)
- N-Methyl-N-(pyridin-4-yl)isonicotinamide (CAS 1617537-44-6)
- 15578-73-1 2-Piperidin-2-ylpyridine dihydrochloride 4891AD C10H16Cl2N2 (CAS 15578-73-1)
- 98035-79-1 Small cardioactive peptide A L-Methioninamide, L-alanyl-L-arginyl-L-prolylglycyl-L-tyrosyl-L-leucyl-L-alanyl-L-phenylalanyl-L-prolyl-L-arginyl- SCPA (CAS 98035-79-1)
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