Macitentan Impurity 10 CAS 149506-35-4
| CAS No. | 149506-35-4 |
| Molecular Formula | C11H11BrO4 |
| Molecular Weight | 287.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Macitentan Impurity 10 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Macitentan Impurity 10 (CAS 149506-35-4, C11H11BrO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Macitentan Impurity 10 (C11H11BrO4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 287.11 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C11H11BrO4 |
| Molecular Weight | 287.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Br-containing |
Related Macitentan Standards
- Macitentan Impurity 36 (CAS CATO-C4X-117536)
- Macitentan Impurity 38 (CAS 2211054-17-8)
- Macitentan Impurity 42 (CAS CATO-C4X-117542)
- Macitentan Impurity 9 (CAS 706811-25-8)
- Macitentan impurity 51 (CAS CATO-C4X-117551)
- Macitentan impurity 53 (CAS 2211054-46-3)
- Macitentan Impurity 14 (CAS 2211059-05-9)
- Macitentan Impurity 13 (CAS 3974-18-3)
Recommended Standards
- Linezolid Impurity 57 (CAS 477846-96-1)
- Salbutamol Impurity 183 (CAS CATO-C4X-1176183)
- 401640-94-6 2-Bromo-N-(4-nitrophenyl)butanamide MFCD03014456 (CAS 401640-94-6)
- Salbutamol Impurity 220 (CAS CATO-C4X-1176220)
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- Montelukast Impurity 46 (CAS CATO-C4X-103146)
- (2E)-3-[4-Methoxy-3-(morpholin-4-ylmethyl)phenyl]-acrylic acid (CAS 893732-30-4)
- (+/-)-Heraclenin (CAS 35740-18-2)
- 6-chloro-2,3-dimethyl-2H-pyrazolo[3,4-b]pyridine (CAS 2067257-98-9)
- (3-Bromo-1H-1,2,4-triazol-1-yl)(phenyl)methanone (CAS 129053-62-9)
- tert-Butyl (trans-4-(hydrazinecarbonyl)cyclohexyl)carbamate (CAS 2241484-97-7)
- 1-Boc-4-formyl-azepane (CAS 1065608-54-9)
- Neuropeptide Y, porcine (CAS 82785-45-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com