Saxagliptin Impurity 18 CAS 709031-28-7
| CAS No. | 709031-28-7 |
| Molecular Formula | C12H16O4 |
| Molecular Weight | 224.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Saxagliptin Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Saxagliptin Impurity 18 (CAS 709031-28-7, C12H16O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Saxagliptin Impurity 18 (C12H16O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C12H16O4 |
| Molecular Weight | 224.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
Related Saxagliptin Standards
- Saxagliptin Impurity N38 (CAS 709031-29-8)
- Saxagliptin Impurity 20 (CAS 1564266-79-0)
- Saxagliptin Impurity 46 (CAS 361440-67-7)
- Saxagliptin Impurity 7 (CAS 1564266-54-1)
- Saxagliptin Impurity 8 (CAS 1445592-86-8)
- Saxagliptin Impurity 47 (CAS 197142-36-2)
- Saxagliptin Impurity 9 (CAS 709031-38-9)
- Saxagliptin Impurity 72 (CAS CATO-C4X-104972)
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