3-Chloro-n-(2-fluoro-5-nitrophenyl)propanamide CAS 710295-56-0
| CAS No. | 710295-56-0 |
| Molecular Formula | C9H8ClFN2O3 |
| Molecular Weight | 246.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 3-Chloro-n-(2-fluoro-5-nitrophenyl)propanamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
3-Chloro-n-(2-fluoro-5-nitrophenyl)propanamide (CAS 710295-56-0), molecular formula C9H8ClFN2O3 and molecular weight 246.62 g/mol, is a CATO reference standard with documented purity and traceability.
3-Chloro-n-(2-fluoro-5-nitrophenyl)propanamide (C9H8ClFN2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C9H8ClFN2O3 |
| Molecular Weight | 246.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 5-Chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazole (CAS 1076197-51-7)
- 4-Chloro-6-methyl-7-(trifluoromethyl)quinazoline (CAS 1160994-15-9)
- 3-Chloro-7-(trifluoromethyl)quinolin-4-amine (CAS 1203579-71-8)
- 4-(4-Chloro-3-fluoro-2-hydroxyphenyl)-4-oxobutanoic acid (CAS 1208265-79-5)
- 2-Chloro-4-(trifluoromethyl)quinolin-7-amine (CAS 1416439-79-6)
- 4-Chloro-2-methyl-6-(trifluoromethyl)quinazoline (CAS 1422284-63-6)
- 2-Chloro-8-(trifluoromethyl)quinolin-4-amine (CAS 1708160-46-6)
- 2-Chloro-6-(trifluoromethyl)-3-methylquinoxaline (CAS 98416-73-0)
Recommended Standards
- 3-Chloro-2-(1H-pyrrol-1-yl)-5-(trifluoromethyl)pyridine (CAS 287978-92-1)
- 4-Chloro-3-phenyl-5-(trifluoromethyl)-1H-pyrazole (CAS 235106-13-5)
- 2-chloro-N-(4-fluoro-3-nitrophenyl)propanamide (CAS 731011-93-1)
- 4-Chloro-5-methyl-2-(trifluoromethyl)quinazoline (CAS 219773-99-6)
- 7-(Ethoxymethyl)-1-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine (CAS 1422132-91-9)
- Diethyl (4-hydroxyphenyl)phosphonate (CAS 28255-39-2)
- alpha-(Trifluoromethyl)-DL-phenylalanine, N-CBZ protected (CAS 139520-45-9)
- 3-Bromoquinoline-7-carboxylic acid (CAS 1344046-13-4)
- Methyl 3-[4-nitro-2-(trifluoromethyl)phenoxy]-2-thiophenecarboxylate (CAS 252026-98-5)
- (3,4-Difluorobenzyl)hydrazine (CAS 887595-36-0)
- 3-Bromo-6-fluoro-2-hydroxybenzaldehyde (CAS 199287-82-6)
- N-(3,4-Dimethoxyphenyl)-4-fluorobenzylamine (CAS 1019542-69-8)
- 2-(4-fluorophenyl)sulfanylacetyl chloride (CAS 70932-09-1)
- Semaglutide impurity 289 (CAS CATO-C4X-2226289)
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