Dapagliflozin Impurity 66 CAS 714269-58-6
| CAS No. | 714269-58-6 |
| Molecular Formula | C30H35ClO11 |
| Molecular Weight | 607.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Dapagliflozin Impurity 66 (CAS 714269-58-6, C30H35ClO11) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Dapagliflozin Impurity 66 (C30H35ClO11) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 607.05 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Dapagliflozin Impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C30H35ClO11 |
| Molecular Weight | 607.05 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 196 (CAS CATO-C4X-1138196)
- Dapagliflozin Impurity 28 (CAS 461432-28-0)
- Dapagliflozin Impurity 62 (CAS CATO-C4X-113862)
- Dapagliflozin Impurity 63 (CAS 2768435-31-8)
- Dapagliflozin Impurity 145 (CAS 1971128-00-3)
- Dapagliflozin Impurity 168 (CAS CATO-C4X-1138168)
- Dapagliflozin impurity 219 (CAS 2640125-03-5)
- Dapagliflozin Impurity 169 (CAS CATO-C4X-1138169)
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