Dapagliflozin Impurity 28 CAS 461432-28-0
| CAS No. | 461432-28-0 |
| Molecular Formula | C30H35ClO11 |
| Molecular Weight | 607.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Dapagliflozin Impurity 28.
As a process- or degradation-related impurity, Dapagliflozin Impurity 28 (CAS 461432-28-0, C30H35ClO11) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Dapagliflozin Impurity 28 (C30H35ClO11) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C30H35ClO11 |
| Molecular Weight | 607.05 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 196 (CAS CATO-C4X-1138196)
- Dapagliflozin Impurity 66 (CAS 714269-58-6)
- Dapagliflozin Impurity 62 (CAS CATO-C4X-113862)
- Dapagliflozin Impurity 63 (CAS 2768435-31-8)
- Dapagliflozin Impurity 145 (CAS 1971128-00-3)
- Dapagliflozin Impurity 168 (CAS CATO-C4X-1138168)
- Dapagliflozin impurity 219 (CAS 2640125-03-5)
- Dapagliflozin Impurity 169 (CAS CATO-C4X-1138169)
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