Paclitaxel Impurity 34 CAS 71629-92-0
| CAS No. | 71629-92-0 |
| Molecular Formula | C29H36O10 |
| Molecular Weight | 544.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Paclitaxel Impurity 34 (CAS 71629-92-0, C29H36O10) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Paclitaxel Impurity 34 (C29H36O10) contains a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 544.59 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Paclitaxel Impurity 34 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C29H36O10 |
| Molecular Weight | 544.59 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
Related Paclitaxel Standards
- Paclitaxel Impurity 33 (CAS 92950-42-0)
- Paclitaxel Impurity 31 (CAS 171926-87-7)
- Paclitaxel EP Impurity N (CAS 27548-93-2)
- Paclitaxel Impurity 37 (CAS 31077-81-3)
- Paclitaxel Impurity 54 (CAS CATO-C4X-184254)
- Paclitaxel Impurity 21 (CAS 30244-37-2)
- Paclitaxel side chain acid (CAS 949023-16-9)
- Paclitaxel Impurity 49 (CAS 2180123-01-5)
Recommended Standards
- Docetaxel EP Impurity E (CAS 32981-86-5)
- 5’-O-(4,4’-Dimethoxytrityl)-3’-β-hydroxythymidine (CAS 112501-53-8)
- Docetaxel Impurity 37 (CAS 172018-16-5)
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