Ivermectin EP Impurity H CAS 71837-27-9
| CAS No. | 71837-27-9 |
| Molecular Formula | C41H62O11 |
| Molecular Weight | 730.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ivermectin EP Impurity H.
Ivermectin EP Impurity H (CAS 71837-27-9) is a certified pharmaceutical impurity reference standard with the molecular formula C41H62O11 and a molecular weight of 730.92 g/mol.
The molecular framework of Ivermectin EP Impurity H (C41H62O11) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C41H62O11 |
| Molecular Weight | 730.92 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
Related Ivermectin Standards
- Ivermectin B1b (CAS 70209-81-3)
- Ivermectin EP Impurity J (CAS CATO-C4X-198220)
- Ivermectin EP Impurity A (CAS 65195-55-3)
- Ivermectin AglyconeDiscontinued, see I940805 (CAS 123997-59-1)
- Ivermectin EP Impurity G (CAS 73162-95-5)
- Ivermectin EP Impurity F (CAS CATO-C4X-198213)
- Ivermectin EP Impurity I(Mixture of Diastereomers) (CAS 1135339-49-9)
- Ivermectin impurity 22 (CAS CATO-C4X-198222)
Recommended Standards
- 1,2,3,4,6-Penta-O-benzoyl-D-glucopyranoside (CAS 3006-49-3)
- N-Despropyl Gamithromycin (10,13-Imino Ether) (CAS 145414-17-1)
- [(2R,3R,4S,5S,6R)-3,4,5,6-tetrabenzoyloxytetrahydropyran-2-yl]methyl benzoate (CAS 41569-33-9)
- Erythromycin A 6,9-Iminoether (CAS CATO-C4X-100128)
- Siponimod Impurity 9 (CAS 2746387-13-1)
- Azathioprine Impurity 18 (CAS 304441-06-3)
- Iopamidol Impurity 55 (CAS CATO-C4X-145055)
- 2-Hydroxy-N-(m-tolyl)benzamide (CAS 7133-57-5)
- 3-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-5-methylisothiazole-4-carbonitrile (CAS 338775-63-6)
- Phenylephrine Hydrochloride EP Impurity C (CAS 52093-42-2(free base))
- (2R,4S)-4-fluoro-5-oxopyrrolidine-2-carboxylic acid (CAS 160705-73-7)
- 3,4,8,9-Tetrahydro-2H-pyrido[1,2-a]pyrimidin-6(7H)-one (CAS 1784-72-1)
- 4-Chloro-6-hydroxypyrimidine-5-carbaldehyde (CAS 1627504-57-7)
- Semaglutide (CAS 910463-68-2)
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