2-Chloro-5-ethyl-1,3,4-thiadiazole CAS 71859-81-9
| CAS No. | 71859-81-9 |
| Molecular Formula | C4H5ClN2S |
| Molecular Weight | 148.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
2-Chloro-5-ethyl-1,3,4-thiadiazole (CAS 71859-81-9), molecular formula C4H5ClN2S and molecular weight 148.61 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Chloro-5-ethyl-1,3,4-thiadiazole (C4H5ClN2S) is characterized by a nitrile group, sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H5ClN2S |
| Molecular Weight | 148.61 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 5-Chloro-3-ethyl-1,2,4-thiadiazole (CAS 101258-23-5)
- 5-chloro-4-methylthiazol-2-amine (CAS 5316-76-7)
- 5-chloro-N-methyl-1,3-thiazol-2-amine (CAS 37660-89-2)
- 5-chloro-thiazole-2-carbonitrile (CAS 98020-94-1)
- 4-Chloro-3-methyl-isothiazol-5-ylamine 4539AF 96841-04-2 C4H5ClN2S (CAS 96841-04-2)
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Recommended Standards
- 3-Chlorothiophene-2-methanol (CAS 193602-41-4)
- 2-Methyl-5-chloromethyl-1,3,4-thiadiazole (CAS 75341-23-0)
- 5-(Chloromethyl)-3-methyl-1,2,4-thiadiazole (CAS 163009-79-8)
- 5-(Chloromethyl)thiazol-2-amine (CAS 69341-83-9)
- methyl 5-methylpyrimidine-4-carboxylate (CAS 1803804-13-8)
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- 3-(4-bromophenyl)-4-methylpyrrolidine hydrochloride (CAS 2059989-01-2)
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