Olanzapine EP Impurity C CAS 719300-59-1
| CAS No. | 719300-59-1 |
| Molecular Formula | C18H22ClN4S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Olanzapine EP Impurity C.
As a process- or degradation-related impurity, Olanzapine EP Impurity C (CAS 719300-59-1, C18H22ClN4SCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Olanzapine EP Impurity C (C18H22ClN4SCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H22ClN4S Cl |
| Molecular Weight | 397.36 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Olanzapine Standards
- Olanzapine Impurity 20 (CAS 1017241-34-7)
- Olanzapine Impurity 11 (CAS 1017241-36-9)
- Olanzapine Impurity 19 (CAS 1070876-09-3)
- Olanzapine-d8 (CAS 1093380-13-2)
- Olanzapine Impurity 39 (CAS 1319722-10-5)
- Olanzapine Impurity 9 (CAS 1320360-86-8)
- Olanzapine Impurity 8 (CAS 1320360-87-9)
- Olanzapine (CAS 132539-06-1)
Recommended Standards
- Gemfibrozil EP Impurity I (CAS 149105-25-9)
- Loxoprofen impurity 94 (CAS CATO-C4X-148894)
- Cefpirome Impurity 35 (CAS CATO-C4X-120735)
- [(E)-but-1-enyl]phosphonic acid (CAS 443118-99-8)
- 1-Ethyl-3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 1082503-79-4)
- 4-Chloro-2-propionamidobenzoic acid (CAS 274901-75-6)
- Methyl 2-Amino-2-(3,5-dichlorophenyl)acetate Hydrochloride (CAS 1137447-08-5)
- 5-amino-1-[(2-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide (CAS 93444-91-8)
- 2-Chloro-4-((2-chloro-4-nitrophenoxy)methyl)benzene-1-sulfonyl fluoride (CAS 30936-58-4)
- Peptide Impurity 26 (CAS 1350456-66-4)
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