6-Bromo-[1,2,5]thiadiazolo[3,4-b]pyridine CAS 72023-75-7
| CAS No. | 72023-75-7 |
| Molecular Formula | C5H2BrN3S |
| Molecular Weight | 216.06 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-Bromo-[1,2,5]thiadiazolo[3,4-b]pyridine.
6-Bromo-[1,2,5]thiadiazolo[3,4-b]pyridine (CAS 72023-75-7) is a high-purity analytical reference standard with the molecular formula C5H2BrN3S and a molecular weight of 216.06 g/mol.
The molecular framework of 6-Bromo-[1,2,5]thiadiazolo[3,4-b]pyridine (C5H2BrN3S) is characterized by a nitrile group, sulfur-containing functionality, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H2BrN3S |
| Molecular Weight | 216.06 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Bromo Standards
- 3-Bromo-6-isothiocyanatopyridazine (CAS 1192814-50-8)
- 6-Bromo-[1,2,3]thiadiazolo[5,4-b]pyridine (CAS 1823290-67-0)
- 7-Bromo-4-fluoroindoline (CAS 1065185-57-0)
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Recommended Standards
- 5,7-Dichloro-3,4-dihydroisoquinolin-1(2H)-one (CAS 885273-81-4)
- 6-Bromothiazolo[4,5-b]pyrazine (CAS 87444-40-4)
- 5,6-Dichloro-3-methyl-2,3-dihydro-1H-indol-2-one (CAS 801300-14-1)
- Lofexidine Nitrile Impurity (CAS 78302-27-9)
- 5-(Chloromethyl)-2-(difluoromethyl)pyridine (CAS 946578-34-3)
- 1-Chloro-2,6-difluoro-3-ethoxybenzene (CAS 1805526-83-3)
- 4-Cyclopropoxypicolinonitrile (CAS 1243285-32-6)
- 1-(5-Ethynylpyridin-3-yl)ethan-1-one (CAS 1256788-24-5)
- tert-Butyl 3-hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate (CAS 374795-42-3)
- [2-(4-Chloro-phenyl)-oxazol-4-yl]-methanol (CAS 22087-22-5)
- N-(4-Amino-2-chlorophenyl)isobutyramide (CAS 741271-91-0)
- Macitentan Impurity 13 (CAS 2089065-77-8)
- (4-Pyridyl)acetone Hydrochloride (CAS 70199-62-1)
- DAPK Substrate Peptide (CAS 386769-53-5)
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