3-Amino-2-chloro-5-methoxypyridine CAS 720666-45-5
| CAS No. | 720666-45-5 |
| Molecular Formula | C6H7ClN2O |
| Molecular Weight | 158.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3-Amino-2-chloro-5-methoxypyridine (CAS 720666-45-5) is a high-purity analytical reference standard with the molecular formula C6H7ClN2O and a molecular weight of 158.59 g/mol.
The molecular framework of 3-Amino-2-chloro-5-methoxypyridine (C6H7ClN2O) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H7ClN2O |
| Molecular Weight | 158.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Amino Standards
- (3-Amino-2-chloropyridin-4-yl)methanol (CAS 1002129-57-8)
- 2-Amino-5-chloro-4-methylpyridin-3-ol (CAS 1003710-95-9)
- (3-Amino-6-chloropyridin-2-yl)methanol (CAS 1206454-48-9)
- (5-Amino-2-chloropyridin-4-yl)methanol (CAS 1227583-24-5)
- 4-Amino-2-chloro-3-methoxypyridine (CAS 1227600-23-8)
- (6-Amino-5-chloropyridin-3-yl)methanol (CAS 1251924-45-4)
- 2-Amino-4-chloro-6-methoxypyridine (CAS 1261628-71-0)
- (6-Amino-3-chloropyridin-2-yl)methanol (CAS 1333779-89-7)
Recommended Standards
- 3,5-Dimethyl-1H-pyrazole-1-carbonyl chloride (CAS 49652-39-3)
- 3-Amino-2-chloro-6-methoxypyridine (CAS 34392-85-3)
- 3,4-Dimethyl-1H-pyrazole-1-carbonyl chloride (CAS 67514-63-0)
- 3-Amino-5-chloro-4-methylpyridin-2(1H)-one (CAS 34040-81-8)
- 2-(4-Methylphenyl)-2,3-dihydropyridazin-3-one (CAS 14135-64-9)
- (2S)-2-hydroxyhexanoic acid (CAS 70267-26-4)
- (E)-3-(4-Fluoro-2-methoxyphenyl)acrylic acid (CAS 913699-84-0)
- N-Desmethyl Zolmitriptan-d3 Hydrochloride (CAS 1795786-26-3)
- N-(3-Cyano-4,5-dimethylthiophen-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide (CAS 896303-39-2)
- Amoxicillin Impurity 32 (CAS CATO-C4X-114832)
- 3,6-Bis(benzyloxy)pyridazine (CAS 4603-62-7)
- (1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)boronic acid (CAS 223418-73-3)
- Josamycin EP Impurity F (CAS 22875-15-6)
- D-Asp9-Tirzepatide (CAS CATO-CPTD788923)
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