Donepezil Impurity 60 CAS 7216-42-4
| CAS No. | 7216-42-4 |
| Molecular Formula | C6H5NO2 |
| Molecular Weight | 123.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Donepezil Impurity 60 (CAS 7216-42-4, C6H5NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Donepezil Impurity 60 (C6H5NO2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 123.11 g/mol, it falls into the low-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Donepezil Impurity 60 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H5NO2 |
| Molecular Weight | 123.11 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Nitrogen Atoms | 1 |
Related Donepezil Standards
- Donepezil Impurity 17 (CAS 127399-78-4)
- Donepezil Impurity 18 (CAS 90843-62-2)
- Donepezil Intermediate 21 (CAS 6443-72-7)
- Donepezil EP impurity B (CAS 2107-69-9)
- Donepezil Aldehyde Impurity (CAS 22065-85-6)
- Donepezil Impurity 16 (CAS 36517-91-6)
- Donepezil Impurity 14 (CAS 148517-82-2)
- Donepezil Impurity 19 (CAS 870555-76-3)
Recommended Standards
- (2-Ethoxyimino) Malononitrile (CAS 84981-58-8)
- Pyrimidine-2-carboxamide (CAS 88511-48-2)
- Pyrimidine-5-carboxamide (CAS 40929-49-5)
- Nicotinic Acid EP Impurity E (CAS 55-22-1)
- Ampicillin Impurity 74 (CAS CATO-C4X-144374)
- Apalutamide Impurity 105 (CAS CATO-C4X-2749105)
- Cefminox Impurity 38 (CAS CATO-C4X-192638)
- 2-Chloro-5-iodo-4,6-dimethylpyridin-3-amine (CAS 2197057-54-6)
- 1-(2-Chlorophenyl)-1H-imidazole-2-sulfonamide (CAS 89517-97-5)
- Dexmedetomidine Impurity 70 (CAS CATO-C4X-123070)
- tert-Butyl 2-(6-hydroxy-4-methylpyridin-3-yl)pyrrolidine-1-carboxylate (CAS 1352521-07-3)
- 2-Amino-N-((2S)-2-(benzyl(isopropyl)amino)cyclohexyl)propanamide (CAS 1354032-75-9)
- (2R,2'R,3R,3'R)-4,4'-bis(benzyloxy)-3,3'-di-tert-butyl2,2',3,3'-tetrahydro-2,2'-bibenzo[d][1,3]oxaphosphole (CAS 1994323-92-0)
- (DTyr27,36,DThr32)-Neuropeptide Y (27-36) (CAS 163887-48-7)
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