2-(3-Bromophenyl)-8-chloroquinoline-4-carboxylic acid CAS 725217-59-4
| CAS No. | 725217-59-4 |
| Molecular Formula | C16H9BrClNO2 |
| Molecular Weight | 362.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-(3-Bromophenyl)-8-chloroquinoline-4-carboxylic acid (C16H9BrClNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 2-(3-Bromophenyl)-8-chloroquinoline-4-carboxylic acid (CAS 725217-59-4), a certified reference material (molecular formula C16H9BrClNO2, MW 362.61 g/mol) for analytical method development and quality control.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H9BrClNO2 |
| Molecular Weight | 362.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromophenyl Standards
- 2-(3-Bromophenyl)-6-chloroquinoline-4-carboxylic acid (CAS 932796-23-1)
- 2-(4-Bromophenyl)-6-chloroquinoline-4-carboxylic acid (CAS 342017-94-1)
- 2-(4-Bromophenyl)-8-chloroquinoline-4-carboxylic acid (CAS 863207-54-9)
- 4-(2-Bromophenyl)-2-chloro-6-methyl-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carbonitrile (CAS 1707585-55-4)
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Recommended Standards
- 1,3-Bis(3-glycidyloxypropyl)tetramethyldisiloxane (CAS 126-80-7)
- Resmetirom impurity 95 (CAS CATO-C4X-291295)
- 6-Bromo-2-(2-chlorophenyl)quinoline-4-carboxylic acid (CAS 445289-24-7)
- Resmetirom impurity 71 (CAS CATO-C4X-291271)
- Quinoline-2,5-diamine (CAS 1421314-22-8)
- Methyl 2-isothiocyanato-3-thiophenecarboxylate (CAS 126637-07-8)
- 3,4-Dihydro-2(1H)-isoquinolinyl(4,5,6,7-tetra-hydro-1H-pyrazolo[4,3-c]pyridin-3-yl)methanone HCl (CAS 1219957-23-9)
- N-Methyl-6-(trifluoromethyl)pyridin-2-amine (CAS 1242339-20-3)
- 1-(Vinylsulfonyl)butane (CAS 16841-53-5)
- Myristoylamide Propylbetaine (CAS 59272-84-3)
- 2-Methoxy-N-(4-(pyrrolidin-1-yl)phenyl)acetamide (CAS 1090371-41-7)
- Azathioprine Impurity 8 (CAS 50-66-8)
- 3-(4-Bromo-2-methoxyphenyl)oxetan-3-ol (CAS 1467060-99-6)
- Neuropeptide Y (porcine) trifluoroacetate salt (CAS 83589-17-7)
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