Resmetirom impurity 95 CAS CATO-C4X-291295
| CAS No. | CATO-C4X-291295 |
| Molecular Formula | C13H10Cl3N3O3 |
| Molecular Weight | 362.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Resmetirom impurity 95 (CAS CATO-C4X-291295, C13H10Cl3N3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Resmetirom impurity 95 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 362.60 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Resmetirom impurity 95 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H10Cl3N3O3 |
| Molecular Weight | 362.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Resmetirom Standards
- Resmetirom impurity 71 (CAS CATO-C4X-291271)
- Resmetirom impurity 129 (CAS CATO-C4X-2912129)
- Resmetirom Impurity 61 (CAS CATO-C4X-291261)
- Resmetirom Impurity 36 (CAS CATO-C4X-291236)
- Resmetirom impurity 72 (CAS 1581304-51-9)
- Resmetirom impurity 77 (CAS CATO-C4X-291277)
- Resmetirom Impurity 39 (CAS CATO-C4X-291239)
- Resmetirom Impurity 40 (CAS 2947651-03-6)
Recommended Standards
- 1,3-Bis(3-glycidyloxypropyl)tetramethyldisiloxane (CAS 126-80-7)
- 2-(Quinolin-8-yloxy)-N-(2,2,2-trichloroacetoxy)acetimidamide (CAS 88758-81-0)
- 2-(3-Bromophenyl)-6-chloroquinoline-4-carboxylic acid (CAS 932796-23-1)
- 7-(Chlorodifluoromethyl)-2-(3,4-dichlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidine (CAS 860610-15-7)
- Efinaconazole Impurity 17 (CAS CATO-C4X-124317)
- Diclofenac impurity 4 (CAS 1928-49-0)
- Risdiplam impurity 7 (CAS CATO-C4X-30127)
- 2,5-Dinitroaniline (CAS 619-18-1)
- 4,4-Dimethyl-2-(methylamino)pentan-1-ol (CAS 1310244-92-8)
- 2,4-Dibromo-6-(difluoromethoxy)phenol (CAS 1804515-86-3)
- 3-(4-Bromo-2-isopropylphenoxy)azetidine (CAS 1220027-28-0)
- 1-(3,4-Dimethoxyphenyl)cyclobutanecarboxylic Acid (CAS 147406-22-2)
- Boc-(R)-4-[2-(trifluoromethyl)benzyl]-L-proline (CAS 957311-13-6)
- α Bag Cell Peptide (1-9) (CAS 87549-52-8)
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