Ifosfamide Impurity 1 CAS 72578-71-3
| CAS No. | 72578-71-3 |
| Molecular Formula | C7H13Cl2N2O3P |
| Molecular Weight | 275.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Ifosfamide Impurity 1 (CAS 72578-71-3) is a certified pharmaceutical impurity reference standard with the molecular formula C7H13Cl2N2O3P and a molecular weight of 275.07 g/mol.
Ifosfamide Impurity 1 (C7H13Cl2N2O3P) contains an amide group, a phosphonate group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H13Cl2N2O3P |
| Molecular Weight | 275.07 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.5 |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Ifosfamide Standards
- Ifosfamide Impurity 6 (CAS CATO-C4X-20016)
- Ifosfamide Impurity 7 (CAS 2649320-48-7)
- Ifosfamide-d4 (CAS 1189701-13-0)
- Ifosfamide (CAS 3778-73-2)
- Ifosfamide EP Impurity F (CAS 81485-04-3 & 40722-73-4)
- Ifosfamide EP Impurity A (CAS 22608-58-8)
- Ifosfamide EP Impurity E (CAS 42453-19-0)
- Ifosfamide EP Impurity B (CAS 241482-18-8)
Recommended Standards
- 668970-56-7 Ethyl (4-bromo-2-fluorophenyl)(oxo)acetate DTXSID90641284 (CAS 668970-56-7)
- 3-Hydroxy Anagrelide-13C3 (CAS 1219393-12-0)
- Methyl 7-bromo-4-fluoro-2,3-dihydrobenzofuran-5-carboxylate (CAS 2253108-16-4)
- Cyclophosphamide impurity 40 (CAS CATO-C4X-230640)
- Edaravone Impurity 14 (CAS CATO-C4X-106214)
- Tizanidine Impurity 6 (CAS 173532-15-5)
- Salbutamol EP impurity N DiFormate (CAS CATO-C4X-117618)
- 3-(5-bromo-4-fluoro-1-oxo-isoindolin-2-yl)piperidine-2,6-dione (CAS 2408391-89-7)
- (S)-1-(3-chloro-4-(trifluoromethyl)phenyl)-2-methylpropan-1-amine (CAS 1212907-63-5)
- 5-Bromo-3-(piperazin-1-yl)pyrazin-2-amine 2,2,2-trifluoroacetate (CAS 1620569-21-2)
- 6-Chloro-n2,n4-bis(4-ethoxyphenyl)-1,3,5-triazine-2,4-diamine (CAS 78912-07-9)
- 2-(7-Hydroxy-2-oxo-2H-chromen-3-yl)acetic acid (CAS 104093-04-1)
- 1-Bromo-2,3,5-trichlorobenzene (CAS 81067-38-1)
- (Leu31,Pro3?)-Neuropeptide Y (human, rat) trifluoroacetate salt (CAS 132699-73-1)
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