Dimethyl 2,3,5,6-tetrafluoroterephthalate CAS 727-55-9
| CAS No. | 727-55-9 |
| Molecular Formula | C10H6F4O4 |
| Molecular Weight | 266.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 266.15 g/mol gives Dimethyl 2,3,5,6-tetrafluoroterephthalate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Dimethyl 2,3,5,6-tetrafluoroterephthalate (CAS 727-55-9), a certified reference material (molecular formula C10H6F4O4, MW 266.15 g/mol) for analytical method development and quality control.
The molecular framework of Dimethyl 2,3,5,6-tetrafluoroterephthalate (C10H6F4O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H6F4O4 |
| Molecular Weight | 266.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Dimethyl Standards
- Dimethyl 3,4,5,6-tetrafluorophthalate (CAS 1024-59-5)
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- 5,5-dimethyl-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-4H,5H,6H-pyrrolo[1,2-b]pyrazole (CAS 2057507-59-0)
- 4-(1,3-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1h-purin-7-yl)butanoic acid (CAS 52083-48-4)
- Dimethyl (4S,5S)-2-phenyl-1,3-dioxolane-4,5-dicarboxylate (CAS 91326-83-9)
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- Methyl 3-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)propanoate (CAS 331972-26-0)
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Recommended Standards
- 4-ACetoxy-2,3,5,6-tetrafluorobenzoic acid methyl ester (CAS 786-52-7)
- 4,4,5,5-Tetramethyl-2-(4-(methylsulfinyl)phenyl)-1,3,2-dioxaborolane (CAS 1016641-70-5)
- (6-bromo-8-fluoro-3-quinolyl)methanol (CAS 2306262-04-2)
- (E)-5-Iododec-5-ene (CAS 104293-08-5)
- 5-Chloro-4-fluoro-2-(4-fluorophenyl)benzofuran-3-carbaldehyde (CAS 1449332-86-8)
- 4-Methyl-3-(methylthio)-5-phenyl-4H-1,2,4-triazole (CAS 25812-76-4)
- 2-(4-Methyl-1H-1,2,3-triazol-1-yl)ethan-1-amine (CAS 1086601-35-5)
- 3-(5-Bromopyridin-3-yl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole (CAS 1707727-59-0)
- tert-Butyl ((1-(6-(cyclopropylamino)pyrimidin-4-yl)piperidin-4-yl)methyl)carbamate (CAS 1353989-86-2)
- Methyl (R)-3-(benzyloxy)-2-hydroxypropanoate (CAS 209907-54-0)
- tert-Butyl 4-oxo-3-(trimethylsilyl)piperidine-1-carboxylate (CAS 2167960-80-5)
- Ethyl 2-fluoro-4-(methylamino)-5-nitrobenzoate (CAS 1219119-52-4)
- 3-(Dimethylamino)-2-iodoacrylaldehyde (CAS 1228184-62-0)
- Tau Peptide (301-315) trifluoroacetate salt (CAS 330456-48-9)
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