4-ACetoxy-2,3,5,6-tetrafluorobenzoic acid methyl ester CAS 786-52-7
| CAS No. | 786-52-7 |
| Molecular Formula | C10H6F4O4 |
| Molecular Weight | 266.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-ACetoxy-2,3,5,6-tetrafluorobenzoic acid methyl ester.
4-ACetoxy-2,3,5,6-tetrafluorobenzoic acid methyl ester (CAS 786-52-7) is a high-purity analytical reference standard with the molecular formula C10H6F4O4 and a molecular weight of 266.15 g/mol.
The molecular framework of 4-ACetoxy-2,3,5,6-tetrafluorobenzoic acid methyl ester (C10H6F4O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-ACetoxy-2,3,5,6-tetrafluorobenzoic acid methyl ester meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H6F4O4 |
| Molecular Weight | 266.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related ACetoxy Standards
- 2-(4-Acetoxy-2-(hydroxymethyl)-1,3-dioxolan-2-yl)benzoic acid (CAS 145354-82-1)
- 2-Acetoxy-3-cyanobenzophenone (CAS 890099-31-7)
- 2-Acetoxy-4-cyanobenzophenone (CAS 890099-34-0)
- 3-Acetoxy-3-cyanobenzophenone (CAS 890099-69-1)
- 2-Acetoxy-2,3-methylbenzophenone (CAS 890099-00-0)
- 2-Acetoxy-2,4-methylbenzophenone (CAS 890099-03-3)
- 2-Acetoxy-2,5-methylbenzophenone (CAS 890099-06-6)
- 2-Acetoxy-2,6-methylbenzophenone (CAS 890099-09-9)
Recommended Standards
- (6-bromo-8-fluoro-3-quinolyl)methanol (CAS 2306262-04-2)
- Dimethyl 2,3,5,6-tetrafluoroterephthalate (CAS 727-55-9)
- Methyl 2-(3-fluoro-4-(trifluoromethoxy)phenyl)-2-oxoacetate (CAS 1443340-78-0)
- 4,4,5,5-Tetramethyl-2-(4-(methylsulfinyl)phenyl)-1,3,2-dioxaborolane (CAS 1016641-70-5)
- (R)-(1-Isocyanoethyl)benzene (CAS 21872-33-3)
- 4-Bromo-2-fluoro-N-methylaniline (CAS 213190-12-6)
- Acetic acid, 2-[(2-methoxyethyl)amino]-2-oxo-, ethyl ester (CAS 349119-43-3)
- Methyl (5-aminothiazol-2-yl)carbamate (CAS 1421602-04-1)
- tert-Butyl (R)-2-(2,4-dimethoxybenzyl)piperazine-1-carboxylate (CAS 1260592-82-2)
- (E)-3-((4-hydroxyphenyl)imino)indolin-2-one (CAS 42407-83-0)
- 4-Fluoro-9-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-5H-benzo[7]annulen-3-yl pivalate (CAS 2226905-74-2)
- 2,2′-(4′-Bromo-3′-methyl[1,1′-biphenyl]-2,6-diyl)bis[4,5-dihydro-4,4-dimethyloxazole] (CAS 108780-74-1)
- 2,3-Difluoro-4-(2-hydroxypropan-2-yl)benzoic acid (CAS 1895670-52-6)
- Insulin Degludec Impurity 5 (CAS CATO-C4X-21575)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com