Cefixime EP Impurity E CAS 72701-01-0
| CAS No. | 72701-01-0 |
| Molecular Formula | C15H15N5O7S2 |
| Molecular Weight | 441.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Cefixime EP Impurity E.
Cefixime EP Impurity E (CAS 72701-01-0) is a certified pharmaceutical impurity reference standard with the molecular formula C15H15N5O7S2 and a molecular weight of 441.44 g/mol.
The molecular framework of Cefixime EP Impurity E (C15H15N5O7S2) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Cefixime EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H15N5O7S2 |
| Molecular Weight | 441.44 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 2 |
Related Cefixime Standards
- Cefixime Impurity 73 (CAS CATO-C4X-113973)
- Cefixime Side Chain Acid Active Ester (CAS 89605-09-4)
- Cefixime Impurity 41 (CAS CATO-C4X-113941)
- Cefixime Impurity 42 (CAS CATO-C4X-113942)
- Cefixime Impurity 27 (CAS 29126-11-2)
- Cefixime (CAS 79350-37-1)
- Cefixime Impurity 14 (CAS CATO-C4X-113914)
- Cefixime Impurity 15 (CAS CATO-C4X-113915)
Recommended Standards
- N-(9-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-(((S)-tetrahydrofuran-2-yl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (CAS 87872-85-3)
- Cariprazine Ethyl Methyl Impurity (CAS 839712-23-1)
- N-(9-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-(((R)-tetrahydrofuran-2-yl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (CAS 87865-88-1)
- Delamanid Impurity 6 (CAS 1318735-00-0)
- Fluticasone Impurity 65 (CAS 74131-81-0)
- Alanyl Glutamine Impurity 7 (CAS CATO-C4X-19747)
- Cefpodoxime Impurity 62 (CAS CATO-C4X-157962)
- 2-(6-(2-Hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone sulfate (CAS 1354784-35-2)
- 2-(3-Hydroxypiperidin-1-yl)-N-(5-methylisoxazol-3-yl)acetamide (CAS 1211303-08-0)
- 6-Hydroxy-N-(m-tolyl)nicotinamide (CAS 565175-25-9)
- N-(3,4-Dichlorophenyl)-N-(methylsulfonyl)glycine (CAS 431979-36-1)
- 6,8-Difluoro-1-(2-oxopropyl)quinolin-4(1H)-one (CAS 1211250-18-8)
- (5Z)-5-(1H-indol-3-ylmethylene)imidazolidine-2,4-dione (CAS 5453-51-0)
- C-Type Natriuretic Peptide (32-53) (human, porcine, rat) (CAS 127869-51-6)
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