2-Chloro-5-fluoro-n-(2-methoxyphenyl)-4-pyrimidinamine CAS 727422-01-7

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-5-fluoro-n-(2-methoxyphenyl)-4-pyrimidinamine.

2-Chloro-5-fluoro-n-(2-methoxyphenyl)-4-pyrimidinamine (CAS 727422-01-7) is a high-purity analytical reference standard with the molecular formula C11H9ClFN3O and a molecular weight of 253.66 g/mol.

Structurally, 2-Chloro-5-fluoro-n-(2-methoxyphenyl)-4-pyrimidinamine (C11H9ClFN3O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 253.66 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 2-Chloro-5-fluoro-n-(2-methoxyphenyl)-4-pyrimidinamine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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