Losartan Impurity 21 CAS 727718-93-6
| CAS No. | 727718-93-6 |
| Molecular Formula | C22H22ClN9 |
| Molecular Weight | 447.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Losartan Impurity 21 (CAS 727718-93-6) is a certified pharmaceutical impurity reference standard with the molecular formula C22H22ClN9 and a molecular weight of 447.92 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Losartan Impurity 21 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 447.92 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Losartan Impurity 21 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H22ClN9 |
| Molecular Weight | 447.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 9 |
Related Losartan Standards
- Losartan Impurity 38 (CAS CATO-C4X-168338)
- Losartan Impurity 40 (CAS CATO-C4X-168340)
- Losartan Impurity 41 (CAS CATO-C4X-168341)
- Losartan Impurity 50 (CAS CATO-C4X-168350)
- Losartan Carboxylic Acid-d4 (CAS 1246820-62-1)
- Losartan-d3 Carboxylic Acid (CAS 1189729-40-5)
- Losartan Impurity 53 (CAS 2904682-23-9)
- Losartan Impurity 54 (CAS 2904682-22-8)
Recommended Standards
- Tecloftalam (CAS 76280-91-6)
- 4-(1,3-Dithiolan-2-yl)-2-methoxy-6-nitrophenyl 4-chlorobenzenesulfonate (CAS 331461-14-4)
- Bisacodyl Impurity 22 (CAS CATO-C4X-203722)
- tert-Butyl (R)-4-(2-(4-chloro-2-fluorophenyl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidine-1-carboxylate (CAS 2401894-42-4)
- Tetrabenazine Impurity 45 (CAS CATO-C4X-274845)
- Peramivir Impurity 9 TFA salt (CAS 229614-37-3(free base))
- Sumatriptan Impurity 9 (CAS 85952-29-0)
- (2S)-2-Amino-3-methylpentanenitrile hydrochloride (CAS 1212491-08-1)
- (R)-1-(3-fluoro-4-methylphenyl)butan-1-amine (CAS 1213336-62-9)
- 3,6-Difluoro-2-methoxybenzenesulfonamide (CAS 1208076-26-9)
- 2-Oxazolidinone, 5-(hydroxymethyl)-3-phenyl- (CAS 29218-21-1)
- 2,3,6-Trichlorotoluene (CAS 2077-46-5)
- Ozenoxacin Impurity 27 (CAS CATO-C4X-279627)
- (Pro30,Tyr32,Leu34)-Neuropeptide Y (28-36) (CAS 161650-01-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com