Losartan Impurity 50 CAS CATO-C4X-168350
| CAS No. | CATO-C4X-168350 |
| Molecular Formula | C22H22Cl2N6 |
| Molecular Weight | 441.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Losartan Impurity 50 (CAS CATO-C4X-168350) is a certified pharmaceutical impurity reference standard with the molecular formula C22H22Cl2N6 and a molecular weight of 441.36 g/mol.
The molecular framework of Losartan Impurity 50 (C22H22Cl2N6) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H22Cl2N6 |
| Molecular Weight | 441.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Losartan Standards
- Losartan Carboxylic Acid-d4 (CAS 1246820-62-1)
- Losartan-d3 Carboxylic Acid (CAS 1189729-40-5)
- Losartan Impurity 53 (CAS 2904682-23-9)
- Losartan Impurity 54 (CAS 2904682-22-8)
- Losartan Impurity 19 (CAS 114798-94-6)
- Losartan impurity 31 (CAS CATO-C4X-168331)
- Losartan Impurity 14 (CAS 124750-92-1)
- Losartan Impurity 44 (CAS CATO-C4X-168344)
Recommended Standards
- Dolutegravir Impurity 52 (CAS CATO-C4X-162052)
- 1-(3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (CAS 320418-37-9)
- Andarine (CAS 401900-40-1)
- 1-(4-(Tert-butyl)phenyl)-5-(2,4-dichlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole (CAS 301194-31-0)
- Captopril impurity 5 (CAS CATO-C4X-11905)
- Mosapride Impurity 5 (CAS CATO-C4X-10445)
- Cefuroxime Impurity 76 (CAS CATO-C4X-124576)
- 2,3-Dichloro-6-methoxypyridine (CAS 83732-68-7)
- 1-(7-Chloro-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (CAS 78104-41-3)
- 6-Methoxy-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde (CAS 1190315-42-4)
- [1,2,4]Triazolo[4,3-a]pyrimidine-6-carboxylic acid (CAS 1368381-98-9)
- (3Z)-3-[(Phenylamino)methylidene]-1,3-dihydro-2-benzofuran-1-one (CAS 477851-24-4)
- (3R,4R)-Benzyl 3-amino-4-hydroxypiperidine-1-carboxylate (CAS 1270497-22-7)
- Semaglutide impurity 67 (CAS CATO-C4X-222667)
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