Phenyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate CAS 72850-69-2
| CAS No. | 72850-69-2 |
| Molecular Formula | C11H5ClF3NO2S |
| Molecular Weight | 307.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Phenyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate (CAS 72850-69-2), molecular formula C11H5ClF3NO2S and molecular weight 307.68 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Phenyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate (C11H5ClF3NO2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Phenyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H5ClF3NO2S |
| Molecular Weight | 307.68 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- (3-Bromopropyl)(isopropyl)sulfane (CAS 112981-26-7)
- 2,3-Dimethyl-6-phenyl-5,6-dihydro-4H-pyrrolo-[1,2-a]thieno[3,2-f][1,4]diazepine (CAS 1170926-91-6)
- 1-(4-Methoxyphenyl)-3-(2-(thiophen-3-yl)ethyl)urea (CAS 1251681-89-6)
- 3,5-Dimethyl-6-(pent-3-en-1-yl)benzofuran-7-ol (CAS 195067-54-0)
- 4-Bromo-1-((tetrahydro-2h-pyran-2-yl)methyl)-1h-pyrazol-3-amine (CAS 1247784-58-2)
- Neostigmine Impurity N3 (CAS 64051-18-9)
- Ethyl 2-chloro-3-fluoro-5-methylbenzoate (CAS 1805226-25-8)
- Tau Peptide (301-315) trifluoroacetate salt (CAS 330456-48-9)
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