Etoricoxib Impurity 49 CAS 73312-69-3
| CAS No. | 73312-69-3 |
| Molecular Formula | C5H8ClNO |
| Molecular Weight | 133.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Etoricoxib Impurity 49.
As a process- or degradation-related impurity, Etoricoxib Impurity 49 (CAS 73312-69-3, C5H8ClNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Etoricoxib Impurity 49 is typically white to off-white liquid. Its solid-state physicochemical attributes — including a molecular weight of 133.58 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Etoricoxib Impurity 49 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H8ClNO |
| Molecular Weight | 133.58 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Etoricoxib Standards
- Etoricoxib Impurity 90 (CAS CATO-C4X-108090)
- Etoricoxib Impurity 39 (CAS 2457-47-8)
- Etoricoxib Impurity 28 (CAS 5470-70-2)
- Etoricoxib impurity 64 (CAS 65719-09-7)
- Etoricoxib Impurity 49 Sodium Salt (CAS 59273-79-9)
- Etoricoxib Impurity 48 (CAS 50704-42-2)
- Etoricoxib impurity 63 (CAS CATO-C4X-108063)
- Etoricoxib Impurity 37 (CAS 38746-92-8)
Recommended Standards
- 53598-88-2 (+/-)-4-(Chloromethyl)-4-methylazetidin-2-one MFCD19232808 (CAS 53598-88-2)
- N-2-Chloroethyl acrylamide, 97% (CAS 44653-15-8)
- 3-Chloro-4-methylisothiazole (CAS 1072-56-6)
- 5-(Chloromethyl)-3-methyl-4,5-dihydroisoxazole (CAS 69578-12-7)
- Olaparib Impurity 49 (CAS CATO-C4X-113549)
- Flunarizine Impurity 7 (CAS 87166-81-2)
- Bevantolol Impurity 23 (CAS CATO-C4X-241123)
- Nebramine 4 Acetic Acid Salt (CAS CATO-C4X-24772)
- 2-(Aminomethyl)-4-(difluoromethyl)-6-methoxypyridine-3-carboxylic acid (CAS 1361872-12-9)
- (3-Chloro-phenyl)-methanesulfonyl chloride (3-chlorophenyl)methanesulfonyl chloride 24974-73-0 (CAS 24974-73-0)
- 1-((2-Hydroxyethoxy)methyl)-5-methylpyrimidine-2,4(1H,3H)-dione (CAS 68724-11-8)
- N-(4-Chloro-2-nitrophenyl)benzenesulfonamide (CAS 735-58-0)
- 2,4,6-Trimethyl-N-(1-phenylethyl)benzenesulfonamide (CAS 305849-18-7)
- [Glu]17-Semaglutide (CAS CATO-CPTD788604)
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