4-(Trifluoromethyl)quinoline-2,7-diol CAS 73496-29-4
| CAS No. | 73496-29-4 |
| Molecular Formula | C10H6F3NO2 |
| Molecular Weight | 229.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(Trifluoromethyl)quinoline-2,7-diol.
4-(Trifluoromethyl)quinoline-2,7-diol (CAS 73496-29-4) is a high-purity analytical reference standard with the molecular formula C10H6F3NO2 and a molecular weight of 229.16 g/mol.
The molecular framework of 4-(Trifluoromethyl)quinoline-2,7-diol (C10H6F3NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H6F3NO2 |
| Molecular Weight | 229.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
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- Cabazitaxel Impurity 38 (CAS CATO-C4X-111538)
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- 5-(1-(4-Chlorophenoxy)ethyl)-1-((4-chlorophenyl)sulfonyl)-1H-pyrazole (CAS 321574-13-4)
- Relugolix Impurity 68 (CAS CATO-C4X-242968)
- 4-Bromo-N-(3-chloro-4-methoxyphenyl)benzamide (CAS 449166-30-7)
- Semaglutide-d5 (CAS CATO-C4X-2226153)
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