Ranitidine EP Impurity E CAS 73857-20-2
| CAS No. | 73857-20-2 |
| Molecular Formula | C13H22N4O4S |
| Molecular Weight | 330.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ranitidine EP Impurity E (C13H22N4O4S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Ranitidine EP Impurity E (CAS 73857-20-2, C13H22N4O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H22N4O4S |
| Molecular Weight | 330.40 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Ranitidine Standards
- Ranitidine EP Impurity C (CAS 73851-70-4)
- Ranitidine Impurity 28 (CAS CATO-C4X-137028)
- Ranitidine Impurity 1 (CAS 72115-14-1)
- Ranitidine-D6 (CAS 1185514-83-3)
- Ranitidine N,S-Dioxide (CAS 1185237-42-6)
- Ranitidine (CAS 66357-35-5)
- Ranitidine EP Impurity D (CAS 117846-02-3)
- Ranitidine Impurity 22 (CAS CATO-C4X-137022)
Recommended Standards
- Pimavanserin Impurity 12 (CAS CATO-C4X-193812)
- Febuxostat Impurity 88 (CAS 144060-84-4)
- Pivmecillinam EP Impurity A (CAS 25031-08-7)
- Febuxostat Impurity 77 (CAS CATO-C4X-116277)
- Fluralaner Impurity 23 (CAS CATO-C4X-218023)
- Enalapril Maleate Impurity 24 (CAS CATO-C4X-133424)
- Phenylephrine Impurity 47 (CAS 57196-61-9)
- 1-(4-(Aminomethyl)-1-methyl-1h-pyrrol-2-yl)-2,2,2-trichloroethan-1-one (CAS 1384430-78-7)
- (Glu9)-Exenatide (2-39) trifluoroacetate salt (CAS 196109-34-9)
- 4-Nitrophenyl (1,1,1-trifluoro-2-methylpropan-2-yl) carbonate (CAS 1098184-18-9)
- 2-Cyclopropyl-6-(m-tolyl)pyrimidin-4-ol (CAS 1710833-97-8)
- Methyl 2-((4-aminopiperidin-1-yl)methyl)benzoate dihydrochloride (CAS 1286272-76-1)
- B-[4-(Dimethylphosphinyl)phenyl]boronic acid (CAS 1376932-77-2)
- Semaglutide impurity 95 (CAS CATO-C4X-222695)
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