Levofolinate EP Impurity H Calcium salt CAS 73951-54-9（Free base）
| CAS No. | 73951-54-9（Free base） |
| Molecular Formula | C20H21N7O7 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Levofolinate EP Impurity H Calcium salt (CAS 73951-54-9（Free base）) is a certified pharmaceutical impurity reference standard with the molecular formula C20H21N7O7Ca and a molecular weight of 511.51 g/mol.
The molecular framework of Levofolinate EP Impurity H Calcium salt (C20H21N7O7Ca) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Levofolinate EP Impurity H Calcium salt under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H21N7O7 Ca |
| Molecular Weight | 511.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 7 |
Related Levofolinate Standards
- Calcium Levofolinate EP Impurity I Calcium salt (CAS 1148151-21-6)
- Calcium Levofolinate Pentahydrate - Impurity G (Dihydrate Salt) (CAS 207226-40-2)
- Calcium Levofolinate EP Impurity F(Calcium salt) (CAS 28459-40-7(free base))
- Calcium Levofolinate EP Impurity I (CAS 31690-11-6)
- Levofolinate Impurity 8 (CAS 4299-32-5)
- Calcium Levofolinate EP Impurity H (CAS 73951-54-9)
- Calcium levofolinate (CAS 80433-71-2)
- Calcium Levofolinate EP Impurity E Calcium salt (CAS 944737-05-7（free base）)
Recommended Standards
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- Gsk2807 (CAS 2245255-65-4)
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- 1,3-Diphenyl-1H-pyrazol-5(4H)-one (CAS 4845-49-2)
- 2,3-Diamino-N-(4-fluoro-3-(trifluoromethyl)phenyl)benzamide (CAS 1421933-30-3)
- Lixisenatide (CAS 320367-13-3（free base）)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com