Butylphthalide Impurity N6 CAS 73959-98-5
| CAS No. | 73959-98-5 |
| Molecular Formula | C8H5Br2F3O |
| Molecular Weight | 333.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Butylphthalide Impurity N6 (C8H5Br2F3O) is characterized by a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Butylphthalide Impurity N6 (CAS 73959-98-5, C8H5Br2F3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5Br2F3O |
| Molecular Weight | 333.93 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | F/Br-containing |
Related Butylphthalide Standards
- Butylphthalide Impurity 81 (CAS 2408731-72-4)
- Butylphthalide Impurity 43 (CAS CATO-C4X-181343)
- Butylphthalide Impurity 61 (CAS 40125-50-6)
- Butylphthalide Impurity 69 (CAS 879627-88-0)
- Butylphthalide Impurity 70 (CAS 102126-70-5)
- Butylphthalide Impurity 71 (CAS 1379356-37-2)
- Butylphthalide Impurity N5 (CAS 169141-21-3)
- Butylphthalide Impurity 29 (CAS CATO-C4X-181329)
Recommended Standards
- 1-(3,4-Dibromophenyl)-2,2,2-trifluoroethan-1-ol (CAS 1613518-85-6)
- 1,2-Dibromo-5-methoxy-3-(trifluoromethyl)benzene (CAS 2383345-61-5)
- 1-(3,5-Dibromophenyl)-2,2,2-trifluoroethan-1-ol (CAS 1613518-82-3)
- 1-Bromo-2-(bromomethyl)-4-(trifluoromethoxy)benzene (CAS 886763-13-9)
- Latanoprost Impurity 25 (CAS CATO-C4X-194125)
- Ticarcillin Impurity 8 (CAS CATO-C4X-17638)
- Plerixafor Impurity 33 DiHCl (CAS CATO-C4X-113333)
- 1H-Pyrazole-5-carbothioamide (CAS 1314902-85-6)
- Evocalcet impurity 54 (CAS CATO-C4X-248554)
- Chlorofluoroacetyl Chloride (CAS 359-32-0)
- 2,4-Dimethylbenzoyl chloride (CAS 21900-42-5)
- Methyl 2-[(oxetan-3-yl)amino]propanoate (CAS 1512660-12-6)
- 5-Chloro-2-fluorobenzenethiol (CAS 1208076-47-4)
- Cholecystokinin, CCK Tetrapeptide (30-33) (CAS 35144-91-3)
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