Solifenacin EP impurity G CAS 740780-79-4
| CAS No. | 740780-79-4 |
| Molecular Formula | C23H26N2O2 |
| Molecular Weight | 362.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Solifenacin EP impurity G (C23H26N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Solifenacin EP impurity G (CAS 740780-79-4, C23H26N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H26N2O2 |
| Molecular Weight | 362.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Nitrogen Atoms | 2 |
Related Solifenacin Standards
- Solifenacin (CAS 242478-37-1)
- Solifenacin EP Impurity H (CAS 732228-02-3)
- Solifenacin Succinate EP Impurity F (CAS 774517-20-3)
- Solifenacin Impurity 8 (CAS CATO-C4X-10538)
- Solifenacin Related Compound 29 (CAS 861998-77-8)
- Solifenacin EP Impurity I (CAS 180272-28-0)
- Solifenacin Impurity 29 (CAS CATO-C4X-105329)
- Solifenacin Impurity 37 (CAS CATO-C4X-105337)
Recommended Standards
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