4-((3-Chloro-4-fluorophenyl)amino)-7-ethoxy-6-nitroquinoline-3-carbonitrile CAS 740791-06-4
| CAS No. | 740791-06-4 |
| Molecular Formula | C18H12ClFN4O3 |
| Molecular Weight | 386.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 4-((3-Chloro-4-fluorophenyl)amino)-7-ethoxy-6-nitroquinoline-3-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
4-((3-Chloro-4-fluorophenyl)amino)-7-ethoxy-6-nitroquinoline-3-carbonitrile (CAS 740791-06-4) is a high-purity analytical reference standard with the molecular formula C18H12ClFN4O3 and a molecular weight of 386.76 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 4-((3-Chloro-4-fluorophenyl)amino)-7-ethoxy-6-nitroquinoline-3-carbonitrile is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 386.76 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C18H12ClFN4O3 |
| Molecular Weight | 386.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
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- 5-(2-Chloro-4-(trifluoromethyl)phenoxy)-3-propoxyisobenzofuran-1(3H)-one (CAS 99199-20-9)
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Recommended Standards
- 1,2,3,4,7,8-Hexachlorodibenzofuran 13C12 (CAS 114423-98-2)
- Tert-butyl(2-chloro-4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)dimethylsilane (CAS 1150561-59-3)
- 2,2,2-Trifluoroethyl (4-((4-chlorophenyl)carbamoyl)benzyl)carbamate (CAS 860649-84-9)
- 1,2,3,6,7,8-Hexachlorodibenzofuran 13C12 (CAS 116843-03-9)
- Ramelteon RC 8 (CAS 1246820-32-5)
- 3-(4-Chloro-phenyl)-7-hydroxy-chromen-4-one (CAS 15485-81-1)
- (E)-3-(4-nitrophenyl)acrylonitrile (CAS 29246-70-6)
- 5-(Trimethylstannyl)-2'-deoxyuridine (CAS 146629-34-7)
- 2-Bromo-4-(bromomethyl)furan (CAS 92753-15-6)
- Benzo[d][1,3]dioxol-5-yl(3,5-dimethyl-1H-pyrazol-1-yl)methanone (CAS 108132-58-7)
- 4-Bromo-2-cyanobenzo[d]oxazole (CAS 1806517-33-8)
- 9-Bromo-N,N-dimethyl-9H-fluoren-2-amine hydrobromide (CAS 7153-54-0)
- Phenol, 4-(4-methyl-1-piperazinyl)- (CAS 163210-63-7)
- Peptide Impurity (CAS CATO-CPTD788810)
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