2-Amino-5-chloro-3-(trifluoromethyl)benzonitrile CAS 74396-76-2
| CAS No. | 74396-76-2 |
| Molecular Formula | C8H4ClF3N2 |
| Molecular Weight | 220.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Amino-5-chloro-3-(trifluoromethyl)benzonitrile (CAS 74396-76-2), molecular formula C8H4ClF3N2 and molecular weight 220.58 g/mol, is a CATO reference standard with documented purity and traceability.
2-Amino-5-chloro-3-(trifluoromethyl)benzonitrile (C8H4ClF3N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 2-Amino-5-chloro-3-(trifluoromethyl)benzonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4ClF3N2 |
| Molecular Weight | 220.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Amino Standards
- 2-Amino-4-chloro-5-(trifluoromethyl)benzonitrile (CAS 1217302-11-8)
- 2-Amino-3-chloro-5-(trifluoromethyl)benzonitrile (CAS 133013-29-3)
- 5-Amino-4-chloro-2-(trifluoromethyl)benzonitrile (CAS 1805524-35-9)
- 4-Amino-3-chloro-5-(trifluoromethyl)benzonitrile (CAS 62584-25-2)
- 4-Amino-5-chloro-2-(trifluoromethyl)benzonitrile (CAS 888073-09-4)
- 2-Amino-5-(chloromethyl)-4-(difluoromethyl)nicotinaldehyde (CAS 1805333-65-6)
- 2-Amino-6-(chloromethyl)-4-(difluoromethyl)nicotinaldehyde (CAS 1805333-76-9)
- 4-Amino-6-(difluoromethyl)-5-methylpicolinoyl chloride (CAS 1805361-73-2)
Recommended Standards
- 3-Chloro-7-(trifluoromethyl)imidazo[1,2-a]pyridine (CAS 1956382-80-1)
- 2-Chloro-6-(trifluoromethyl)benzimidazole (CAS 86604-86-6)
- 6-Chloro-2-(trifluoromethyl)imidazo[1,2-a]pyridine (CAS 189116-20-9)
- 4-Chloro-2-ethynyl-1-(trifluoromethoxy)benzene (CAS 1860576-02-8)
- Pyribencarb (CAS 799247-52-2)
- Ethyl 5-chloro-1H-pyrrolo[3,2-b]pyridine-3-carboxylate (CAS 2090915-34-5)
- 4-Amino-3-fluoro-5-(trifluoromethyl)benzoic acid (CAS 1805485-68-0)
- N-methylspiro[2.3]Hexane-1-carboxamide (CAS 1385031-06-0)
- 295803-03-1 Tetracosanamide,N-[(1S,2S,3R,7E)-2,3-dihydroxy-1-(hydroxymethyl)-7-heptadecen-1-yl]-2-hydroxy-,(2R)- (CAS 295803-03-1)
- Ethyl 2-(quinoxalin-2-yloxy)acetate (CAS 439106-63-5)
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- 3-Amino-5-hydroxybenzoic Acid Hydrochloride (CAS 14206-69-0)
- 69558-55-0 O3Y80ZF13F Thymopentin Thymopentin [USAN:INN:BAN] L-Tyrosine, N-(N-(N-(N2-L-arginyl-L-lysyl)-L-alpha-aspartyl)-L-valyl)- L-Tyrosine, N-(N-(N-(N(sup 2)-L-arginyl-L-lysyl)-L-alpha-aspartyl)-L-valyl)- Thymopentine [French] Thymopentinum [Latin] Timopentina [Spanish] Thymopoietin 32-36 TP-5 Thymopoietin pentapeptide ORF-15244 Thymopentine Thymopentinum Timopentina ORF 15244 UNII-O3Y80ZF13F (CAS 69558-55-0)
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