1-(Difluoromethoxy)-3,5-bis(trifluoromethyl)benzene CAS 745030-84-6
| CAS No. | 745030-84-6 |
| Molecular Formula | C9H4F8O |
| Molecular Weight | 280.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 1-(Difluoromethoxy)-3,5-bis(trifluoromethyl)benzene (CAS 745030-84-6), a certified reference material (molecular formula C9H4F8O, MW 280.11 g/mol) for analytical method development and quality control.
Based on its molecular formula C9H4F8O, 1-(Difluoromethoxy)-3,5-bis(trifluoromethyl)benzene contains a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 280.11 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(Difluoromethoxy)-3,5-bis(trifluoromethyl)benzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H4F8O |
| Molecular Weight | 280.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- 1-(Difluoromethoxy)-2,4-bis(trifluoromethyl)benzene (CAS 1805562-53-1)
- 2-(2-(Difluoromethoxy)-6-methoxybenzoyl)pyridine (CAS 1261468-22-7)
- 2-(4-(Difluoromethoxy)-3-methoxybenzoyl)pyridine (CAS 1261619-89-9)
- 2-(4-(Difluoromethoxy)-2-methoxybenzoyl)pyridine (CAS 1261677-77-3)
- (3-(Difluoromethoxy)-4-methoxyphenyl)(pyridin-4-yl)methanone (CAS 1261677-95-5)
- 2-(2-(Difluoromethoxy)-3-methoxybenzoyl)pyridine (CAS 1261799-26-1)
- 2-{[4-(difluoromethoxy)phenyl]amino}benzoic acid (CAS 51679-46-0)
- {3-[4-(difluoromethoxy)-3-methoxyphenyl]-1,2,4-oxadiazol-5-yl}acetonitrile (CAS 852399-91-8)
Recommended Standards
- (3-Bromo-2-(2,2-difluoropropoxy)phenyl)methanamine (CAS 2161982-96-1)
- 1,1-Bis(2-chloroethyl)-2-((5-nitrofuran-2-yl)methylene)hydrazine (CAS 19819-37-5)
- 2-Chloro-N-(3-chlorophenyl)-9H-purin-6-amine (CAS 190654-76-3)
- 2-(2,4-Dichlorophenyl)-1H-imidazo[4,5-b]pyridin-1-ol (CAS 339028-17-0)
- 4-Amino-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,5-diol (CAS 14133-36-9)
- 4-(2-Chloroethyl)-3,5-dimethyl-1H-pyrazole (CAS 79379-05-8)
- 1-(2-Hydroxyacetyl)piperidin-4-one (CAS 1248290-09-6)
- (3-Isopropyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-2-yl)methanamine (CAS 1782371-92-9)
- 2-Amino-4-[4-(benzyloxy)phenyl]-6-(hydroxymethyl)-8-oxo-4H,8H-pyrano[3,2-b]pyran-3-carbonitrile (CAS 664999-58-0)
- N-(3-(2-Phenyl-1H-imidazol-1-yl)propyl)furan-2-carboxamide (CAS 95082-37-4)
- Fosfomycin Trometamol EP Impurity A (CAS 84954-80-3)
- Upadacitinib Impurity 108 (CAS CATO-C4X-2405108)
- N-(4-Bromo-2-chlorophenyl)-3-methylbenzamide (CAS 902092-48-2)
- Semaglutide Impurity 164 (CAS CATO-C4X-2226164)
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