4-[4-(4-Chloro-phenoxy)-phenyl]-2,4-dioxo-butyric acid ethyl ester CAS 74649-80-2
| CAS No. | 74649-80-2 |
| Molecular Formula | C18H15ClO5 |
| Molecular Weight | 346.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-[4-(4-Chloro-phenoxy)-phenyl]-2,4-dioxo-butyric acid ethyl ester (CAS 74649-80-2) is a high-purity analytical reference standard with the molecular formula C18H15ClO5 and a molecular weight of 346.76 g/mol.
4-[4-(4-Chloro-phenoxy)-phenyl]-2,4-dioxo-butyric acid ethyl ester (C18H15ClO5) contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-[4-(4-Chloro-phenoxy)-phenyl]-2,4-dioxo-butyric acid ethyl ester meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H15ClO5 |
| Molecular Weight | 346.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
Related Chloro Standards
- Methyl 4-(4-(4-Chloro-3-methylphenoxy)phenyl)-2,4-dioxobutanoate (CAS 1159980-99-0)
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- N-(4-chloro-3-(trifluoromethyl)phenyl)-2-(pyridin-2-ylthio)acetamide (CAS 329078-60-6)
- 1380572-33-7 5-Chloro-3-(3,4,5-trimethoxy-phenylimino)-1,3-dihydro-indol-2-one (CAS 1380572-33-7)
- 1-(5-Chloro-2-nitrophenyl)-6,7-dimethoxy-3,4-dihydroisoquinoline (CAS 62206-13-7)
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Recommended Standards
- 3-{[(4-chlorophenyl)methyl]sulfanyl}-5-(trifluoromethyl)pyridine-2-carboxamide (CAS 338406-83-0)
- N-allyl-4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-pyrazole-1-carbothioamide (CAS 306976-64-7)
- Dacomitinib Impurity 26 (CAS CATO-C4X-208626)
- 5-Chloro-2-(4-fluorophenyl)-4-(4-methoxyphenoxy)pyridazin-3(2H)-one (CAS 478049-35-3)
- N-(3-chloro-4-methylphenyl)-5-oxopyrrolidine-2-carboxamide (CAS 1009340-97-9)
- 1,7-Dimethyl-3,4-dihydroisoquinoline (CAS 33456-86-9)
- (E)-4-(Ethoxymethylene)-2-phenyloxazol-5(4H)-one (CAS 57784-65-3)
- 3,4-Dibromothiophene 1,1-dioxide (CAS 89088-96-0)
- Brimonidine Impurity 38 (CAS CATO-C4X-156638)
- 3-amino-N-(2-aminoethyl)-3-phenylpropanamide dihydrochloride (CAS 1803600-91-0)
- methyl 8-bromoimidazo[1,2-a]pyridine-6-carboxylate (CAS 1234616-08-0)
- 2-(4-Fluorophenyl)-5-methyl-1-phenyl-1H-pyrrole (CAS 634598-34-8)
- 6-(4-Methoxyphenoxy)hexanoic acid (CAS 132858-54-9)
- Human IgE Pentapeptide HEPP (CAS 62087-72-3)
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