Dacomitinib Impurity 26 CAS CATO-C4X-208626
| CAS No. | CATO-C4X-208626 |
| Molecular Formula | C16H12ClFN4O2 |
| Molecular Weight | 346.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Dacomitinib Impurity 26 (CAS CATO-C4X-208626), a pharmacopoeial impurity reference standard (molecular formula C16H12ClFN4O2, MW 346.74 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Dacomitinib Impurity 26 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 346.74 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures Dacomitinib Impurity 26 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H12ClFN4O2 |
| Molecular Weight | 346.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Dacomitinib Standards
- Dacomitinib Impurity 30 (CAS CATO-C4X-208630)
- Dacomitinib Impurity 39 (CAS CATO-C4X-208639)
- Dacomitinib Impurity 29 (CAS CATO-C4X-208629)
- Dacomitinib Impurity 36 (CAS CATO-C4X-208636)
- Dacomitinib Impurity 41 (CAS CATO-C4X-208641)
- Dacomitinib Impurity 27 (CAS CATO-C4X-208627)
- Dacomitinib Impurity 31 (CAS CATO-C4X-208631)
- Dacomitinib Impurity 4 (CAS 179552-75-1)
Recommended Standards
- 5-Chloro-2-(4-fluorophenyl)-4-(4-methoxyphenoxy)pyridazin-3(2H)-one (CAS 478049-35-3)
- Methyl 4-(4-(4-Chloro-3-methylphenoxy)phenyl)-2,4-dioxobutanoate (CAS 1159980-99-0)
- Bromodiiodomethane (CAS 557-95-9)
- 1556699-61-6 3-[(4-Chloro-6-fluoroquinolin-3-yl)sulfonyl]benzonitrile MFCD22549253 (CAS 1556699-61-6)
- Cabazitaxel Impurity 42 (CAS CATO-C4X-111542)
- Tasimelteon Impurity 1 (CAS 209255-72-1)
- Semaglutide impurity 277 (CAS CATO-C4X-2226277)
- N4-(trans-4-methylcyclohexyl)pyrimidine-2,4-diamine (CAS 1401034-42-1)
- 5'-Bromo-2',6-difluoro-[1,1'-biphenyl]-2-carbonitrile (CAS 425379-21-1)
- 3-(4-Bromophenyl)-1-(p-tolyl)-1H-pyrazole-5-carboxylic acid (CAS 618102-62-8)
- 8-Fluoro-3-iodo-6-methylquinoline (CAS 1592298-19-5)
- Cyclosporin Impurity 16（Dihydrocyclosporin H） (CAS 83602-88-4)
- 2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl(phenyl)methanone (CAS 31337-88-9)
- Semaglutide Impurity 157 (x TFA Salt) (CAS CATO-C4X-2226157)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com