Brimonidine Impurity N3 CAS 1158184-23-6
| CAS No. | 1158184-23-6 |
| Molecular Formula | C13H12BrN5O |
| Molecular Weight | 334.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Brimonidine Impurity N3 (CAS 1158184-23-6) is a certified pharmaceutical impurity reference standard with the molecular formula C13H12BrN5O and a molecular weight of 334.17 g/mol.
Structurally, Brimonidine Impurity N3 (C13H12BrN5O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 334.17 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H12BrN5O |
| Molecular Weight | 334.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 5 |
Related Brimonidine Standards
- Brimonidine Impurity 28 (CAS CATO-C4X-156628)
- Brimonidine Impurity 43 (CAS CATO-C4X-156643)
- Brimonidine Impurity 17 (CAS 134892-47-0)
- Brimonidine-2,3-dione (CAS 182627-95-8)
- Brimonidine Impurity 30 (CAS CATO-C4X-156630)
- Brimonidine Impurity 36 (CAS CATO-C4X-156636)
- Brimonidine Impurity 35 (CAS CATO-C4X-156635)
- Brimonidine Impurity 44 (CAS CATO-C4X-156644)
Recommended Standards
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- 5-Bromo-2-chloro-3-hydroxybenzoic acid (CAS 697762-68-8)
- methyl 4-chloropyrazolo[1,5-a]pyridine-3-carboxylate (CAS 1167056-15-6)
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- 1-((4-Chlorobenzyl)sulfonyl)-2-(3,4-dichlorophenyl)propan-2-ol (CAS 339276-79-8)
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- Calcitonin C-Terminal Flanking Peptide (human) XTFA (CAS 85916-47-8（free base）)
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