Prucalopride Impurity 33 CAS 748788-40-1
| CAS No. | 748788-40-1 |
| Molecular Formula | C22H20Br2Cl2N2O8 |
| Molecular Weight | 671.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Prucalopride Impurity 33.
As a process- or degradation-related impurity, Prucalopride Impurity 33 (CAS 748788-40-1, C22H20Br2Cl2N2O8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Prucalopride Impurity 33 (C22H20Br2Cl2N2O8) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H20Br2Cl2N2O8 |
| Molecular Weight | 671.12 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Prucalopride Standards
- Prucalopride Impurity 1 (CAS CATO-C4X-10381)
- Prucalopride Impurity 20 (CAS CATO-C4X-103820)
- Prucalopride Impurity 47 (CAS 2245785-75-3)
- Prucalopride Impurity 7 (CAS CATO-C4X-10387)
- Prucalopride Impurity 43 (CAS CATO-C4X-103843)
- Prucalopride Impurity 26 (CAS 2250243-46-8)
- Prucalopride Impurity 42 (CAS CATO-C4X-103842)
- Prucalopride Impurity 54 (CAS CATO-C4X-103854)
Recommended Standards
- Perfluorotributylamine (Pftba) (CAS 311-89-7)
- 4,8-Bis((2-hexyldecyl)oxy)benzo[1,2-b:4,5-b']dithiophene (CAS 1254985-73-3)
- Dioctadecyl Phthalate (CAS 14117-96-5)
- Lifitegrast Impurity 137 (CAS CATO-C4X-2409137)
- Cefmenoxime Impurity 1 (CAS 184696-69-3)
- Paroxetine Impurity 57 (CAS CATO-C4X-103557)
- Zidovudine EP Impurity D (CAS 76-84-6)
- N-benzyl-3-chloro-2,2-dimethylpropanamide (CAS 82820-75-5)
- 3-(4-oxo-3,4-dihydroquinazolin-3-yl)propanoic acid (CAS 25818-88-6)
- a-Amino-4-methyl-cyclohexaneacetic acid (CAS 31877-72-2)
- 3-Fluoro-4-[(1-methyl-1h-pyrazol-4-yl)methoxy]aniline (CAS 1006960-98-0)
- 5-Methyl-pyridin-3-ylamine dihydrochloride (CAS 1187932-24-6)
- (2E)-3-(dimethylamino)-1-(pyridin-2-yl)prop-2-en-1-one 2-[3-(Dimethylamino)acryloyl]pyridine 3-(dimethylamino)-1-(pyridin-2-yl)prop-2-en-1-one 66521-54-8 (CAS 66521-54-8)
- Peptide Fmoc-Thi-Thi-OH (CAS CATO-CPTD788552)
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