Lifitegrast Impurity 137 CAS CATO-C4X-2409137
| CAS No. | CATO-C4X-2409137 |
| Molecular Formula | C36H31ClN2O7S |
| Molecular Weight | 671.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Lifitegrast Impurity 137 (CAS CATO-C4X-2409137, C36H31ClN2O7S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lifitegrast Impurity 137 (C36H31ClN2O7S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Lifitegrast Impurity 137 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C36H31ClN2O7S |
| Molecular Weight | 671.16 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 22.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Lifitegrast Standards
- Lifitegrast Impurity 138 (CAS CATO-C4X-2409138)
- Lifitegrast Impurity 76 (CAS CATO-C4X-240976)
- Lifitegrast Impurity 144 (CAS CATO-C4X-2409144)
- Lifitegrast Impurity 145 (CAS CATO-C4X-2409145)
- Lifitegrast Impurity 29 (CAS CATO-C4X-240929)
- Lifitegrast Impurity 30 (CAS 1194550-61-2)
- Lifitegrast Impurity 127 (CAS CATO-C4X-2409127)
- Lifitegrast Impurity 128 (CAS CATO-C4X-2409128)
Recommended Standards
- 4,8-Bis((2-hexyldecyl)oxy)benzo[1,2-b:4,5-b']dithiophene (CAS 1254985-73-3)
- Prucalopride Impurity 33 (CAS 748788-40-1)
- BMS 795311 (CAS 939390-99-5)
- Perfluorotributylamine (Pftba) (CAS 311-89-7)
- Meropenem EP Impurity A (CAS 1053703-36-8)
- Maribavir Impurity 30 (CAS CATO-C4X-300730)
- Estetrol Impurity 2 (CAS CATO-C4X-32502)
- Ceftriaxone Impurity 12 (CAS CATO-C4X-116312)
- (R)-4-Isopropyl-2-(6-methylpyridin-2-yl)-4,5-dihydrooxazole (CAS 2757083-00-2)
- 2,3,4-Trimethoxyphenylboronic acid, pinacol ester (CAS 2121514-09-6)
- 5-methyl-7-nitroindoline-2,3-dione (CAS 90418-79-4)
- 5-(6-Quinolinyl)-3-Isoxazolamine (CAS 1482213-28-4)
- 4,4,5,5-Tetramethyl-2-(pent-1-en-2-yl)-1,3,2-dioxaborolane (CAS 1361046-86-7)
- Endo-Pro36-Tirzepatide (CAS CATO-CPTD788688)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com