tert-Butyl (5-bromo-3-fluoropyridin-2-yl)carbamate CAS 748812-76-2
| CAS No. | 748812-76-2 |
| Molecular Formula | C10H12BrFN2O2 |
| Molecular Weight | 291.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of tert-Butyl (5-bromo-3-fluoropyridin-2-yl)carbamate is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
tert-Butyl (5-bromo-3-fluoropyridin-2-yl)carbamate (CAS 748812-76-2) is a high-purity analytical reference standard with the molecular formula C10H12BrFN2O2 and a molecular weight of 291.12 g/mol.
The molecular framework of tert-Butyl (5-bromo-3-fluoropyridin-2-yl)carbamate (C10H12BrFN2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), tert-Butyl (5-bromo-3-fluoropyridin-2-yl)carbamate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H12BrFN2O2 |
| Molecular Weight | 291.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- tert-Butyl (4-bromo-3-fluoropyridin-2-yl)carbamate (CAS 2680688-10-0)
- tert-Butyl (6-bromo-5-fluoropyridin-3-yl)carbamate (CAS 2750510-49-5)
- 8-Bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyridine (CAS 947533-47-3)
- tert-butyl N-(2-bromo-5-fluoropyridin-3-yl)carbamate (CAS 2680869-45-6)
- 7,8-Dihydro-5H-pyrano[4,3-b]pyridin-2-amine (CAS 1260670-91-4)
- Methyl 2-(5-Bromo-2-hydroxyphenyl)acetate (CAS 220801-66-1)
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