5-(3-Chlorophenyl)pyrimidin-2-ol CAS 74963-17-0
| CAS No. | 74963-17-0 |
| Molecular Formula | C10H7ClN2O |
| Molecular Weight | 206.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
5-(3-Chlorophenyl)pyrimidin-2-ol (CAS 74963-17-0) is a high-purity analytical reference standard with the molecular formula C10H7ClN2O and a molecular weight of 206.63 g/mol.
The molecular framework of 5-(3-Chlorophenyl)pyrimidin-2-ol (C10H7ClN2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 5-(3-Chlorophenyl)pyrimidin-2-ol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H7ClN2O |
| Molecular Weight | 206.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorophenyl Standards
- 2-(4-Chlorophenyl)-3,4-dihydropyrimidin-4-one (CAS 106690-55-5)
- 2-(3-Chlorophenyl)-3,4-dihydropyrimidin-4-one (CAS 106690-56-6)
- 3-(4-Chlorophenyl)pyrimidin-4(3H)-one (CAS 109853-43-2)
- 2-(2-Chlorophenyl)-3,4-dihydropyrimidin-4-one (CAS 1156241-13-2)
- 3-(3-Chlorophenyl)-4,5-dihydroisoxazole-5-carbonitrile (CAS 1160473-09-5)
- 3-(4-Chlorophenyl)-4,5-dihydroisoxazole-5-carbonitrile (CAS 1173119-75-9)
- 1-(4-Chlorophenyl)-1h-pyrazole-5-carbaldehyde (CAS 1266114-21-9)
- 1-(2-Chlorophenyl)-1H-pyrazole-5-carbaldehyde (CAS 1269291-08-8)
Recommended Standards
- 5-(3-Chlorophenyl)pyrazin-2(1H)-one (CAS 88066-89-1)
- 5-(4-Chlorophenyl)-1,2,4-triazin-3-amine (CAS 886497-46-7)
- 5-(3-Chlorophenyl)-2-furaldehyde (CAS 22078-59-7)
- 5-(4-Chlorophenyl)-1,2-dihydropyrazin-2-one (CAS 36932-77-1)
- 5-(Benzyloxy)-1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indole (CAS 151387-71-2)
- 2-Chloro-3-(piperidin-1-ylmethyl)pyridine (CAS 1250675-90-1)
- 1-aminobutane-2,3-diol (CAS 1432491-99-0)
- 3-Phenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine (CAS 1202800-71-2)
- 7-Bromo-2-(hydroxymethyl)-4H-pyrido[1,2-a]pyrimidin-4-one (CAS 926236-92-2)
- Methyl({[4-(2-methylpropyl)phenyl]methyl})amine (CAS 1079178-51-0)
- Tri([1,1'-biphenyl]-4-yl)methanol (CAS 5341-14-0)
- 4-(4-Ethoxy-3-methylphenyl)-2-hydrazinyl-5-methylthiazole (CAS 1416338-65-2)
- (4S)-4-Benzyl-3-(5,5,5-trifluoropentanoyl)-1,3-oxazolidin-2-one (CAS 1401065-46-0)
- (DTyr27,36,DThr32)-Neuropeptide Y (27-36) (CAS 163887-48-7)
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